Immunology Final Exam Questions and answers all correct
11) Group 1 ILCs are typically activated in response to infections caused by which of the
following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Correct Answer: Viruses
11) Group 2 ILCs are typically activated in response to infections caused by which of the
following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Correct Answer: Helminths
11) Why are neutrophil transfusions rarely used in treatment of Severe Combined Neutropenia
(SCN)?
-It's difficult to find a matching donor
-The volume of serum needed complicates transfusions
-Neutrophils are short lived and most would die within a day
-The foreign neutrophils could contain intracellular bacteria
-It's more appropriate to use a macrophage transfusion Correct Answer: Neutrophils are short
lived and most would die within a day
11) Somatic mutations that truncate the intracytoplasmic tail of what receptor increase the risk of
leukemia?
-G-CSF
-CCFR4
-Fc
-IL-4
-CD40 Correct Answer: G-CSF
11) Resolution of an infection typically involves complete clearance of the pathogen, and thus
the source of antigens, over the course of days to weeks, following which most effector
lymphocytes, which is called:
-Clonal die off
-Clonal disambiguation
-Clonal contraction
-Lymphocyte die off
-None of these Correct Answer: Clonal contraction
, 11) If an individual lacked the ability to mount an innate immune response to a pathogen, what
sort of trend would you expect to see in regards to microorganism numbers (assuming no
medical intervention)?
-Sharp increase, followed by a sharp decrease due to the adaptive immune response
-A steep and constant increase
-no increase
-slow increase with steady decline
-none of the above Correct Answer: A steep and constant increase
11) Approximately how many primary immuno-deficiencies have now been described that effect
the development of immune cells, their function, or both?
- >150
- >50
- >1,000
- >1,500
- <50 Correct Answer: >150
11) Which of the following would not be considered a secondary immunodeficency?
- starvation
- adverse side effects of medical intervention
- inheriting a deficient immune regulatory gene
- all of the above
- none of the above Correct Answer: inheriting a deficient immune regulatory gene
11) Recurrent infection by pyogenic, or pus-forming, bacteria suggests a defect in antibody,
complement, or which cell type?
- cytotoxic T cells
- Macrophages
- Natural killer cells
- Dendritic cells
- Helper T cells Correct Answer: Macrophages
11) If an individual has a history of persistent fungal skin infection, such as cutaneous
candidiasis, or recurrent viral infections suggests a defect in host defense mediated by what cell
type?
- Natural Killer cells
- B cells
- neutrophils
- macrophages
- T-cells Correct Answer: T-cells
1) When using FACS (flow cytometry) to determine whether a person has normal lymphocyte
levels, you find there is no fluorescence from the CD3 antibody marker that you used. This
would indicate that this person:
-has appropriate numbers of both B and T cells
-Has a B cell deficiency
11) Group 1 ILCs are typically activated in response to infections caused by which of the
following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Correct Answer: Viruses
11) Group 2 ILCs are typically activated in response to infections caused by which of the
following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Correct Answer: Helminths
11) Why are neutrophil transfusions rarely used in treatment of Severe Combined Neutropenia
(SCN)?
-It's difficult to find a matching donor
-The volume of serum needed complicates transfusions
-Neutrophils are short lived and most would die within a day
-The foreign neutrophils could contain intracellular bacteria
-It's more appropriate to use a macrophage transfusion Correct Answer: Neutrophils are short
lived and most would die within a day
11) Somatic mutations that truncate the intracytoplasmic tail of what receptor increase the risk of
leukemia?
-G-CSF
-CCFR4
-Fc
-IL-4
-CD40 Correct Answer: G-CSF
11) Resolution of an infection typically involves complete clearance of the pathogen, and thus
the source of antigens, over the course of days to weeks, following which most effector
lymphocytes, which is called:
-Clonal die off
-Clonal disambiguation
-Clonal contraction
-Lymphocyte die off
-None of these Correct Answer: Clonal contraction
, 11) If an individual lacked the ability to mount an innate immune response to a pathogen, what
sort of trend would you expect to see in regards to microorganism numbers (assuming no
medical intervention)?
-Sharp increase, followed by a sharp decrease due to the adaptive immune response
-A steep and constant increase
-no increase
-slow increase with steady decline
-none of the above Correct Answer: A steep and constant increase
11) Approximately how many primary immuno-deficiencies have now been described that effect
the development of immune cells, their function, or both?
- >150
- >50
- >1,000
- >1,500
- <50 Correct Answer: >150
11) Which of the following would not be considered a secondary immunodeficency?
- starvation
- adverse side effects of medical intervention
- inheriting a deficient immune regulatory gene
- all of the above
- none of the above Correct Answer: inheriting a deficient immune regulatory gene
11) Recurrent infection by pyogenic, or pus-forming, bacteria suggests a defect in antibody,
complement, or which cell type?
- cytotoxic T cells
- Macrophages
- Natural killer cells
- Dendritic cells
- Helper T cells Correct Answer: Macrophages
11) If an individual has a history of persistent fungal skin infection, such as cutaneous
candidiasis, or recurrent viral infections suggests a defect in host defense mediated by what cell
type?
- Natural Killer cells
- B cells
- neutrophils
- macrophages
- T-cells Correct Answer: T-cells
1) When using FACS (flow cytometry) to determine whether a person has normal lymphocyte
levels, you find there is no fluorescence from the CD3 antibody marker that you used. This
would indicate that this person:
-has appropriate numbers of both B and T cells
-Has a B cell deficiency
