Lecture notes
Methods of Post Transcriptional Regulation
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Just a description and summary of the methods used in post-transcriptional regulation. That is the way genes are regulated after transcription.
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POST TRANSCRIPTIONAL EXPRESSION REGULATION, METHOD 2: REGULATION OF NUCLEARTRANSPORT
1.) HIV synthesis
Important genes:
Rev: regulates nuclear export
Tat: regulates the elongation of transcription across the integrated viral genome
Nef: a key factor in pathogenesis and cell infection.
Early synthesis
1.) viral DNA is integrated in the cells genome
2.) Splicesome splice out parts of the mRNA. Leaving some RNA spliced and others unspliced
3.) Only fully spliced RNA containing Rev, Tat, and Nef will get exported from the nucleus and
translated.
Late synthesis
1.) Only after enough Rev protein has entered the cell will the unspliced RNA have a chance to be
exported as well.
2.) Majority of this RNA is translated into protein
3.) Full length transcripts are packaged into new viral particles.
You might notice that the most crucial protein is REV.
- It’s made in the cytosol of the cell
- Binds to specific sequences on introns of HIV transcripts
- Brings unspliced viral RNA out of the nucleus to be packaged.
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