Summary
Samenvatting Hart en vaten 1 - overzicht cardiologie
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Beknopt overzicht van cardiologie (welke factoren bepalen de bloeddruk) + screenshort van de belangrijkste grafieken en hormonen. Score: 18/20
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Hart en vaten 1:overzicht bloeddruk
belangrijkste grafieken en hormonen
, BD
CO SVR CVD
Bloedvolume
Veneuze compliantie
Spierpomp
SVR (OS)
HF SV Vaattonus (constrictie) Viscositeit Veneuze vaattonus (constrictie)
CO
Expiratie en valsalva
Inspiratie
Liggen of hurken
OS ↑bloedvolume via: RAAS,
NO (via PS: ACh, Shear stress,
OS en circulerende ACh op GSC (EC dysfunctie) bradykinine) vasopressine/ADH, aldosteron
PS
catecholamines EDV ESV Myogene respons (venen) ↓bloedvolume via: ANP
GM: β-blokkers Autoreg: reactieve hyperemie
GM: atropine Endotheline, angiotensine 2, PGI2
aldosteron
Preload (voorbelasting) Afterload (nabelasting) Inotropie (contractiliteit)
OS en circulerende
Veneuze druk (zie CVD)
HF catecholamines PS
Compliantie ventrikels
Inotropie ventrikels Druk aorta/a. pulmonalis HF (Boweditch: ↑Na+ = ↑Ca2+) Systolisch falen (ischemie,
Inotropie atria
Inflow weerstand Afterload (Anrep) aritmie, cariomyopathie,...)
Outflow weerstand/afterload
GM: digitalis, PDE-I
, Frank-Starling
- = adaptatiemechanisme van het hart
- “Het hart kan binnen fysiologische grenzen eender welk volume ejecteren tegen eender welke druk door zijn EDV aan te passen”
Toename preload Toename afterload Veranderingen inotropie
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