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Connective Tissue Summary
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Lecture summary of connective tissue
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Connective Tissue•
Cells are separated by extracellular matrix .
cells
In epithelial tissue were
right next to each other
.
is the precursor tissue all connective tissue cells derived from
> •
Mesenchyme embryonal are
✓
,
cells All connective tissue cells the same before specialization
mesenchymal .
are .
(Mesoderm )
→ Extracellular matrix of the connective tissue
types are
very different from each other .
Connective Tissue Types Functional classification of connective tissue cells of connective tissue
→ Loose and dense connective tissue
•
Supportive connective tissue •
Resident cells → stable in a specific
(under the skin) Hendon) •
Metabolic connective tissue tissue
→
Cartilage and bone ( very strong
-
Supply of
oxygen , nutrients
•
Wandering cells → move around
( blood)
→ Drain of
Blood and lymph (liquid connective tissue
-
CO2 ,
metabolites
storage of energy (fat)
-
→ Endothelium and mesothelium
(wall (anatomical membrane in Immunological defense : immune system
-
of blood vessels) the
abdomen)
Resident Cell Types
Mast cells : release histamine that
chondrocytes
cell dilate blood vessels
curses histamine
pre of (during allergic reaction all the They were once
precursor is released the blood vessels wandering cells in
60M
over dilating .
>
blood but turned
lipid cell blood pressure drops and body goes into
into resident cells
shock)
anaphylactic
blood
}
fat cell
makes
vessels macrophages : skin ( cells of Langerhans)
make ,
liver lkupffer ) all part of
collagen abdominal
the immune
membrane lung (dust cells)
brain (microglia) system
bone cell
cartilage cell
Dense connective tissue Ground substance Fibers
•
Fibroblasts : cells with the red nuclei •
Mainly composed
of glycoproteins •
Collagen (Glue)
(sugar + protein) • Reticular
Matrix : in between the cells in blue
Sticky liquid
•
•
• Elastic
↳ 2 compartments •
Macromolecules interact with each other,
Collagen fibers ( blue) with fibers and with cells
•
.
Ground substance
sforthe]
•
1in between the fibers)
→ Fibroblasts are continuously making building block
collagen fibers
liquid with sticky
molecules
Collagen Fibers
Collagen synthesis
•
Used to make glue •
In RER and Golgi
•
If there is not enough vitamin C
Secreted via constitutive route
collagen
•
fibers can not be made
resulting
in
scurvy disease Self of tropo collagen
•
.
assembly
15 different types into collagen fibers in extra -
Type 1 : in tendons and bones (connects muscle to bones)
Type 4 : basal cellular matrix .
thin fibers in cartilage lamina ( collagen fibers are too big
Type 2:
thin fibers in reticular connective tissue to be synthesized at once)
Type 3 :
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