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Summary Glycogenolysis metabolism. (Simple illustration)
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This document provides a simple illustration of Glycogenolysis metabolism in human body. It’s easy to comprehend and good for pre-test review.
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GlycogenolysisÉ
The process of glycogenolysis is breaking down the
Écoge
gÉ
glycogen polymer. This metabolism happens in the liver and
muscle cells when:
phosphorylase
1.The blood glucose level is low (hypoglycemia).
or i
t.si
2. During a fasting state.
3. The stimulation of hormones (Glucagon, epinephrine and
norepinephrine). i
————————
Let's begin the procedures.
Firstly, the Glycogen Phosphorylase enzyme flings the
phosphate group to an alpha-1,4-glycosidic bond to break
the bond and form one molecule called Glucose-1-P. And it
keeps adding the phosphate to the other bonds. Until it
stops at the fourth glucose away from the a-1,6-
glycosidic bond. The transfer of the phosphates onto the
glucose is performed by Pyridoxal phosphate (PLP). It's a
derivative of vitamin B6. Gas
any
Another enzyme will continue the work by cutting the
a-1,4-Glycosidic bond between the first and second j p
glucose. And then transfer the three glucose molecules to
D p p D
another branch. After that, he will release the last glucose
molecule on the branch by cutting an a-1,6-glycosidic bond.
D p
a
This enzyme is called (The debranching enzyme). The
activities of this enzyme are a-1,4-glycosidase, three
µ D p D P
D
glucose transfers and a-1,6-glycosidase.
Pgp D p
Then again, the glycogen phosphorylase will keep doing its
work at the new branching stopping at the fourth glucose
o.o
as usual. And then, another enzyme will continue the work.
However, as we can see, these enzymes release much
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