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Responsiecollege bioinformatica

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Responsiecollege aantekeningen bio informatica

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  • December 4, 2022
  • 2
  • 2019/2020
  • Class notes
  • Luc michiels
  • Rc
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RESPONSIECOLLEGE BIO-
INFORMATICA
EXPECTED PROPORTIONS AND BLOSSOM SCORE

DIA 23



DIA 24



VERWACHTE GELIJKHEID BERKENEN VAN SEQUENTIE MBV PAM

DIA 29

PAM => evolutionaire dicht gerelateerde families bekijken

*niet meer symmetrisch => 1 substitutie op honderd aminozuren, wat is nu de kans dat we 2
substituties hebben

Vermenigvuldigingen doen met deze matrix kan beetje de evolutie beschrijven



OVERVIEW OF TYPICAL PROTEOMICS WORKFLOW

VANAF DIA 20

Berekenen van Blossom matrix => we gaan uit van blokken zeer sterk geallyneerde eiwitten.

Hoe komen we ook alweer aan de 60 in de noemer. We kunnen in dit geval dus 5 rijen
vergelijken met elkaar, daarna kunnen we nog maar 4 rijen vergelijken en zo komen we tot
1. Omdat we dit 4 keer hebben krijgen we 60.

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