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Responsiecollege bioinformatica
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Responsiecollege aantekeningen bio informatica
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RESPONSIECOLLEGE BIO-INFORMATICA
EXPECTED PROPORTIONS AND BLOSSOM SCORE
DIA 23
DIA 24
VERWACHTE GELIJKHEID BERKENEN VAN SEQUENTIE MBV PAM
DIA 29
PAM => evolutionaire dicht gerelateerde families bekijken
*niet meer symmetrisch => 1 substitutie op honderd aminozuren, wat is nu de kans dat we 2
substituties hebben
Vermenigvuldigingen doen met deze matrix kan beetje de evolutie beschrijven
OVERVIEW OF TYPICAL PROTEOMICS WORKFLOW
VANAF DIA 20
Berekenen van Blossom matrix => we gaan uit van blokken zeer sterk geallyneerde eiwitten.
Hoe komen we ook alweer aan de 60 in de noemer. We kunnen in dit geval dus 5 rijen
vergelijken met elkaar, daarna kunnen we nog maar 4 rijen vergelijken en zo komen we tot
1. Omdat we dit 4 keer hebben krijgen we 60.
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