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Veterinary medicine - disorders of erythrocytes
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disorders of erythrocytes
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PATHOLOGY LEC – DISORDERS OF ERYTHROCYTES & LEUKOCYTESDISORDERS OF ERYHTROCYTES CAUSES OF ALTERED MEAN
• Erythropoiesis CORPUSCULAR VOLUME
INCREASED MCV Regenerative anemia,
FeLV /
myeloproliferative
ds, aged blood
sample,
autoagglutination,
hyperosmolality
DECREASED MCV Iron deficiency,
anemia of chronic
inflamm ds,
hyponatremia
INCREASED Intravascular
MCHC hemolysis, lipemia /
numerous Heinz
bodies, spherocytosis,
hyponatremia
DECREASED Regenerative anemia,
MCHC iron deficiency, aged
blood
NON-REGENERATIVE ANEMIA
• MCHC & MCV – normocytic &
normochromic
• Reticulocyte count – no increased release
of reticulocytes
REGENERATIVE ANEMIA • Blood film morphology – uniform in size
Can be identified using the ff: & polychromatic cells are rare
CAUSES OF NON-REGENERATIVE ANEMIA
• MCHC & MCV
• Red cell cytograms • Primary bone marrow ds
• Reticulocyte count o Aplastic anemia, pure red cell
aplasia, non-regenerative IMHA,
• Blood film morphology
bone marrow neoplasia,
myelofibrosis
• Secondary to inflamm or metabolic ds
• Feline viral infections
• Nutritional deficiencies
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