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Summary PSL372 Action Potential Prelab Notes $8.79   Add to cart
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Summary

Summary PSL372 Action Potential Prelab Notes
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  • Course
  • PSL372
  • Institution
  • University Of Toronto (U Of T )

Ion channels, membrane potential, action potential, gating of voltage-dependent channels, refractory period, ion conductance and permeability, depolarization block, drugs

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Document information

  • December 9, 2022
  • 4
  • 2022/2023
  • Summary

Subjects

  • action potential
  • m gate
  • n gate
  • h gate
  • depolarization block
  • resting membrane potential
  • tetrodotoxin ttx
  • tetraethylammonium tea
  • barium ba2

Written for

  • University of Toronto (U of T )
  • Life Sciences
  • PSL372
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Content preview

372 CAB01 Action Potential
PSL

on channels
specializedmacromoleculartransmembraneproteins
importantforbidirectionaltransportof lipidinsolubleions
requiredto generate
11 membranepotential dmaintaincellvolume
excitablea nonexcitablecells
21 actionpotentials excitablecells
s importantproperties
in ionconduction rapidrateacrossmembrane
21 selectivity ion specificity
31 gating openclosetospecificstimuli
voltagegatedligandgated mechanically gated


Membrane Potential cum definedrelativetocellexterior
dependson
D iondistributionacrossmembrane Ict Nat l l canbedescribedbyGoldman Hodgkin Katz eq
Membranepemeabilitytodifferentions y Um It
Kt o Pna that lot paler
In Pic
p piety t pna that sit PatelJi



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at restingmp.hr
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man
Inotvoltagegated voltagerequiredto maintaina particular is gradient
Kt Nat
Ewat t60mV
Cl outside
Ext goMV
11 kt ions Ear 70mV inside

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KY
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Eventually Iactout Iactin duetoelectricalgradient
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4 depictedby Nernstear
in ex o
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II ex

21 Nations
Natso s Nat
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wever permeability to wat cats is
antetype

si et ions
TenTo s tri
pet isverysmall
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ilychafedproteinsinsidecellkeeps a
ionsoutside

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