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Samenvatting geneeskunde: celbiologie 2 H6
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samenvatting H6 celbiologie 2 voor geneeskunde met duidelijke structuur, afbeeldingen en notities
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MOLECULAR CELL
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Cell is the smallest part of all organisms and it's act like a foundation upon every activity we done.so learn about cell make your foundation strong.
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AP Biology Cell Exam | Questions and Answers 2023/2024
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H6: SIGNAALTRANSDUCTIESIGNAALMOLECULEN EN RECEPTOREN
INLEIDING
Cellulaire communicatie
- Informatie-uitwisseling multicellulair organisme
Cel-cel
Cel-buitenwereld
Cel-interne omgeving
Intercellulaire communicatie
- Signaalcel
Aanmaak en opslag van signaalmolecule
Afgave van signaalmolecule door stimulus
- Transport van signaalmolecule
- Doelwitcel
Binding van signaalmolecule door receptor
Activeren signaaltransductie
Cellulaire respons
- Beëindigen van signaal
SIGNAALMOLECULEN
Chemische identiteit
- Eiwitten en peptiden
Insuline, groeifactoren
- Aminozuren of derivaten
Glutamaat, GABA, glycerine
- Biogene amines
Acetylcholine
Adrenaline
Dopamine
Serotonine
Histamine
- Nucleotiden
ATP, ADP
- Nucleosiden
adenosine
- Steroïden
Glycocorticoïden
Oestrogeen, testosteron, progesteron
- Eicosanoïden
Prostaglandines, leukotriënen
- Gassen
NO, CO
Synthese van signaalmoleculen
- Via algemene metabole paden
Eiwitten, peptiden, az, atp
, - Via specifieke set van enzymatische reacties
Steroidhormonen (vaak uit cholesterol)
Eicosanoïden
Biosynthese eicosanoïden
- Voorloper arachidonzuur
Prostaglandine
Aspirine, iboprofen zijn inhibitoren voor prostaglandine (remt signaalmolecule)
Uit prostaglandine wordt thromboxaan gevormd -> veroorzaakt samenklontering
bloedplaatjes (aspirine -> bloedverdunner)
Afgave van signaalmoleculen
- Geregelde exocytose
Vereist opslag van signaalmolecule in vesikel
Stimulus (ca) voor afgifte
- Diffusie uit cel
NO, steroïden en eicosanoïden (geen vesiculari opslag mogelijk)
Regeling op niveau van synthese
VORMEN VAN COMMUNICATIE
ENDOCRIENE INTERACTIE
PARACRIENE INTERACTIE
, AUTOCRIENE INTERACTIE
JUXTACRIENE INTERACTIE
MEMBRAANRECEPTOREN VS INTRACELLULAIRE RECEPTOREN
- Hydrofiel signaalmolecule
Extracellulaire binding aan receptor in PM
Nood aan intracellulaire signalen -> second messenger
- Hydrofoob signaalmolecule
Diffusie door PM
Binding aan intracellulaire receptor
Intracellulaire receptoren
- Steroïdhormonen
Afgeleid van cholesterol
Hydrofoob (Diffusie door PM)
Binding aan intracellulaire receptor
Translocatie naar kern
Activering of inhibitie genexpressie
Membraanreceptoren
- Binding aan membraanreceptor (extracellulair)
- Signaaltransductie
Extracellulair naar intracellulair signaal
Second messengers
- Cellulaire respons
Second messengers
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