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Zusammenfassung des Knochengewebes Histologie

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Detaillierte Zusammenfassung zum Knochengewebe. Aufbau mit verschiedenen Zellen sowie die Entstehung des Knochens.

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  • No
  • Kapitel 3.2
  • January 5, 2023
  • 13
  • 2021/2022
  • Summary
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KNOCHENGEWEBE

festes , hartes Bindegewebe
der Matrix in die Kalzium salze
Eigenschaften auf
Zusammensetzung




,






metabolische Funktion : Kalzium speicher ( 99% im Knochen )


Speicherung von
Magnesium Phosphat Natriumionen etc
-

,
-




,
.




KNOCHEN MATRIX
=
verkeilt

↳ erlaubt hohe Druck und
Zugfestigkeit
-




30%
organisches Material





1-
D
Kollagen ,
des Typ
→ in lamellen Kollagen parallel zueinander
=




Lamellen eines Ostens Gefäß achse
→ in
Kollagenfasern hetikal um
=




,




D weitere Matrixproteine

Osteokatgin Osleopontin Osteonekin
'

, , ,




n
Proteogly Kane

45% aus
anorganischen Salzen (mineralischem Material )

Hydroxylapatit Mineralisierung
,




kristalline Form des Kalzium phosphats / Hydroxylapatit







Mineralisierung in Matrixvesikeln



25% Wasser

, Osteoblasten


KNOCHEN ZELLEN
- Osteozytes


n
OsteoprogenitorZellen -
:-c:&:

Vorläuferzellen der Osteoblasten


differenzieren aus mlsenchy malen Stammzellen + entwickeln zu

Osteoblasten

Knochen morphogenetische Proteine , Wachstumsfaktoren
gesteuert von
• :





im End Ost + Peri ost


bei Frakturen können aktiviert → teilen dann



☐ Osteoblasten

Knochen bildende Zellen


Kubische , prismatische Form


sind miteinander über Nexus verbunden



Membran reich an alkalischer Phosphatase f- Rolle Mineralisierung )

bilden Knochen matrix ( nicht verkalkte Matrix =
Ostia)


Aktivität wird durch Protein der Osleozylen
gehemmt






entwickeln sich zu OSKOZY XD ,
Ruhezustand , Apoptose
ab 20 nimmt ab

.


Lebensjahr seltener →




D
Osteozyten

sind ausdifferenziert Osteoblasten



liegen in Launen der Knochen matrix


an Oberfläche :
unverkalkle Matrix

verbunden über Gap junction

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