Summary
Samenvatting Aandoeningen Medische Biochemie (J000505A)
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Dit document bevat alle vernoemde aandoeningen opgelijsd met symptomen en werkingsmechanismen (in eigen woorden neergeschreven).
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By: wonderalice256 • 10 months ago
By: nelderuytter • 1 year ago
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GLUCOSEMETABOLISMEAandoening Symptomen Probleem/werking
- Neurologisch voorteken : beven Hersenen hebben weinig reserve aan koolhydraten en zijn afhankelijk van
glycogeen voor een constante bloedglucose spiegel. Bij tekort zullen
Hypoglycemie - Hypoglycemische coma (want hersenen symptomen van neurologische aard snel optreden.
hebben glucose nodig)
Bij insulinoom
- Obesitas => ↗ incidentie diabetes en Basis : Insulinedeficiëntie
atherosclerose
Type II : insuline intolerantie waarbij spier vet en lever resistent zijn tegen
- Blijvend hoge hyperglycemie insuline waardoor glucose niet meer normaal verwerkt kan worden
- Glucosurie Ketonen vorming (acetoacetaat, β-hydroxybutyraat & aceton) => in bloed
Diabetes + H+ : acetoazijnzuur, β-hydroxyboterzuur & aceton => acidose &
- Ketogenese & acidose
ketonemie => ketonurie (aceton & acetoazijnzuur) => verstoring IC & EC
- Ketonurie uit balans --> in elke cel/weefsel gevoeld
- Neurologische symptomen, oftalmologisch,
Behandeling : chloroindolecarboxamides : inhibeert allosterisch
vaatstoornis, wondgenezing, …
glycogeenfosforylase
Effecten agv niet enzymatisch glycosylatie van diverse proteïnen
- Retinopathie, nefropatie, neuropathie Consequenties komen sterk tot uiting bij ongecontroleerde diabetici
Hyperglycemie
- vasculaire complicaties patiënten
Diagnose : ↗6% Hb1Ac (geglycosyleerd Hb A)
- ↗ incidentie diabetes en atherosclerose
Meer vet bevoorraden => BV ↗ => BD ↗ => arbeid hart ↗ => verdikking
Obesitas
- ↗ cholesterolconcentratie en TGwaarden hartspier
- Hyperinsulinemie
Insulinoom Tumor β cellen => overmatige productie insuline
- hypoglycemie
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