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Samenvatting Overzicht van hoofdstuk 7: pancytopenie $3.80   Add to cart

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Samenvatting Overzicht van hoofdstuk 7: pancytopenie

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Dit is een overzicht van hoofdstuk 7: pancytopenie

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  • January 8, 2023
  • 3
  • 2020/2021
  • Summary
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PANCYTOPENIE – overzicht
ALGEMEEN Pancytopenie = vermindering in absolute getallen van de 3 reeksen in het perifeer bloed ➔ anemie + leukopenie + trombocytopenie
Bicytopenie → als 2 van de 3 reeksen gedaald zijn
OORZAKEN VERMINDERDE BLOEDCELAANMAAK IN BEENMERG
• Aplastische of hypoplastisce anemie → beenmergaplasie of beenmerghypoplasie
• Ten gevolge van vitamine B12 - of folaat deficiënte
• Ten gevolge van myeloftyse (leukemie, lymfoom, myeloom, metastatisch carcinoom, myelofibrose, myelodysplastische syndromen)
• Ten gevolge van infectie met inname van beenmerg (bv bij TBC)
VERHOOGDE PERIFERE AFBRAAK
• SLE
• Paroxysmale nachtelijke hemoglobinurie
• Ikv hypersplenisme
o Wordt gekenmerkt door triade: pancytopenie, spenomegalie en verdwijnen van pancytopenie na splenectomie
o Oorzaken:
▪ Lymfomen
▪ Stapelingsziekte bv Gaucher
▪ Felty syndroom (= neutropenie ikv RA)
DIAGNOSE Beenmergonderzoek!!!
• Beenmerguitstrijkjes op draagglaasjes
• Beenmerg- of botbiopt dmv anatomopathologie

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