100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Samenvatting Pathologische fysiologie (Carmeliet) $8.27   Add to cart

Summary

Samenvatting Pathologische fysiologie (Carmeliet)

 87 views  2 purchases
  • Course
  • Institution

Dit document bevat alle hoofdstukken van het deel 'pathologische fysiologie' van ziektemechanismen. Dit vak werd gegeven door prof. Carmeliet.

Preview 4 out of 53  pages

  • January 9, 2023
  • 53
  • 2022/2023
  • Summary
avatar-seller
INHOUD

Inleiding................................................................................................................................................................... 5
Situering van de discipline pathologische fysiologie ........................................................................................... 5
Definities ............................................................................................................................................................. 5
Activiteit .......................................................................................................................................................... 5
Pathologisch .................................................................................................................................................... 6
Huidige doodsoorzaken ...................................................................................................................................... 6
Levensexpectantie .............................................................................................................................................. 6
Veroudering ........................................................................................................................................................ 6
Meten van ‘veroudering’................................................................................................................................. 6
Veroudering vs leeftijdsgebonden ziekten...................................................................................................... 6
Cellulaire en moleculaire oorzaken van veroudering...................................................................................... 7
Schade aan macromoleculen ...................................................................................................................... 7
Inadequaat herstel van schade ................................................................................................................... 7
Ontregeling van de homeostase van celaantal ........................................................................................... 8
Kenmerken van veroudering ........................................................................................................................... 8
Veroudering vertragen .................................................................................................................................... 9
Deel I: capita selecta uit de algemene fysiopathologie....................................................................................... 10
Hoofdstuk 1: het ‘local adaptation syndrome’: de acute ontstekingsreactie ....................................................... 10
Inleiding............................................................................................................................................................. 10
Pathofysiologie van de acute ontstekingsreactie.............................................................................................. 10
Fase 1: vasculaire elementen van de ontstekingsreactie.................................................................................. 11
Pathofysiologie .............................................................................................................................................. 11
Biochemische mediatoren ............................................................................................................................ 12
Fase 2: cellulaire elementen van de ontstekingsreactie ................................................................................... 15
Pathofysiologie .............................................................................................................................................. 15
Biochemische aspecten ................................................................................................................................. 16
Stoornissen in de cellulaire fase .................................................................................................................... 17
Verdere evolutie ............................................................................................................................................... 17
Algemene weerslag van de acute ontstekingsreactie ....................................................................................... 18
Hoofdstuk 2: koorts en andere stoornissen van thermoregulatie ........................................................................ 19
Inleiding............................................................................................................................................................. 19
Fysiologie van thermoregulatie......................................................................................................................... 19
Effector-apparaat .......................................................................................................................................... 19
Warmte-productie en aanpassingsmechanismen..................................................................................... 19
Warmte-afgave en aanpassingsmechanismen ......................................................................................... 20


1

, Sensor-apparaat ............................................................................................................................................ 21
Set-point........................................................................................................................................................ 22
Pathofysiologie van de thermoregulatie ........................................................................................................... 22
Koorts ............................................................................................................................................................ 22
Pathofysiologie .......................................................................................................................................... 22
Klinisch voorkomen en begeleidende verschijnselen ............................................................................... 23
Behandeling .............................................................................................................................................. 24
Hyperthermie ................................................................................................................................................ 24
Oorzaken ................................................................................................................................................... 24
Verwikkelingen van hyperthermie ............................................................................................................ 25
Hypothermie ................................................................................................................................................. 25
Hoofdstuk 3: voeding en metabolisme ................................................................................................................. 27
Normale voedingsbehoeften mens ................................................................................................................... 27
Essentiële nutritionele behoeften................................................................................................................. 27
Energie ...................................................................................................................................................... 27
Eiwit........................................................................................................................................................... 27
Lipiden en koolhydraten ........................................................................................................................... 28
Vitaalstoffen .............................................................................................................................................. 28
Water en elektrolyten ............................................................................................................................... 28
Aanbevolen hoeveelheden ........................................................................................................................... 28
Factoren die behoefte aan nutriënten beïnvloeden ..................................................................................... 29
Malnutritie ........................................................................................................................................................ 29
Eiwit – energie............................................................................................................................................... 29
Marasmus-like ........................................................................................................................................... 29
Kwashiorkor-like........................................................................................................................................ 29
Hypometabole en hypermetabole toestanden ............................................................................................. 30
Hormonen ................................................................................................................................................. 30
Hypermetabool: metabolisme – eiwit – glucose....................................................................................... 31
Hypometabool: metabolisme – eiwit – glucose ........................................................................................ 31
Kanker cachexie ............................................................................................................................................ 31
Regeling energiebalans en obesitas .................................................................................................................. 32
Energiebalans ................................................................................................................................................ 32
Energie-inname (appetijt) ......................................................................................................................... 32
Energieverbruik ......................................................................................................................................... 32
Obesitas......................................................................................................................................................... 32
Etiologie .................................................................................................................................................... 33
Pathogenese.............................................................................................................................................. 33

2

,Deel II: stoornissen van homeostasemechanismen ............................................................................................ 34
Hoofdstuk 1: calcium ............................................................................................................................................ 34
Fysiologische aspecten ...................................................................................................................................... 34
Homeostase serum calcium .......................................................................................................................... 34
Voeding en turn-over van bot ....................................................................................................................... 34
Hormonale controle van calciumhomeostase .............................................................................................. 35
Parathyroïdhormoon (parathormoon) ...................................................................................................... 35
Vitamine D................................................................................................................................................. 35
Calcitonine ................................................................................................................................................ 36
Pathofisiologie van calciumhomeostase ........................................................................................................... 36
Hypocalcemie ................................................................................................................................................ 36
Oorzaken ................................................................................................................................................... 36
Symptomen ............................................................................................................................................... 37
Beandeling................................................................................................................................................. 37
hypercalcemie ............................................................................................................................................... 38
Oorzaken ................................................................................................................................................... 38
Symptomen ............................................................................................................................................... 38
Behandeling .............................................................................................................................................. 39
DEEL III: capita selecta uit orgaan- en systeem fysiopathologie ......................................................................... 40
Hoofdstuk 1: Pathofysiologie van ademhalingsstelsel .......................................................................................... 40
Pathofysiologie van hypoxie en hypercapnie.................................................................................................... 40
Hypoxie ......................................................................................................................................................... 41
Oorzaken ................................................................................................................................................... 41
Symptomen en begeleidende verschijnselen ........................................................................................... 41
Hypercapnie .................................................................................................................................................. 42
Oorzaken ................................................................................................................................................... 42
Symptomen en begeleidende verschijnselen ........................................................................................... 42
Belangrijkste vormen van longpathologie ........................................................................................................ 42
Obstructieve aandoeningen .......................................................................................................................... 42
Astma ........................................................................................................................................................ 43
Chronisch obstructief longlijden (COPD) ................................................................................................... 44
Restrictieve aandoeningen............................................................................................................................ 45
Interstitieel longlijden (longparenchym)................................................................................................... 45
Pneumonie (longparenchym) .................................................................................................................... 46
Atelectase (longparenchym) ..................................................................................................................... 46
Pleura ........................................................................................................................................................ 46
Thorax ....................................................................................................................................................... 46

3

, Vasculaire aandoeningen .............................................................................................................................. 46
Pulmonale hypertensie ............................................................................................................................. 46
Longstuwing en longoedeem .................................................................................................................... 47
Longembool .............................................................................................................................................. 47
Hoofdstuk 2: fysiopathologie van cardiovasculair stelsel ..................................................................................... 49
Syncope ............................................................................................................................................................. 49
Circulatoire oorzaken .................................................................................................................................... 49
Syncope door arteriolaire vasodilatatie .................................................................................................... 49
Cardiale vormen van syncope ................................................................................................................... 50
Niet-circulatoire oorzaken ............................................................................................................................ 50
Hartfalen ........................................................................................................................................................... 51
Syptomen ...................................................................................................................................................... 51
Pathofysiologie .............................................................................................................................................. 51
Hartfalen met gedaalde ejectiefractie ...................................................................................................... 51
Hartfalen met bewaarde ejectiefractie ..................................................................................................... 51
Shock ................................................................................................................................................................. 52
Indeling obv pathogenese ............................................................................................................................. 52
Hypovolemische shock .............................................................................................................................. 52
Cardiogene shock ...................................................................................................................................... 52
Algemene pathofysiologie van shock ............................................................................................................ 52
Symptomen ................................................................................................................................................... 53




4

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller zGNK. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $8.27. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

79271 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$8.27  2x  sold
  • (0)
  Add to cart