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Chapter 6 practice questions metabolism and toxicology
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This document provides the practice questions on the topics of chapter 6.
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1. Xenobiotic biotransformation is performed by multiple enzymes in multiplesubcellular locations. Where would one of these enzymes most likely NOT be
located?
- Golgi apparatus.
2. All of the following statements regarding hydrolysis, reduction, and oxidation
biotransformations are true EXCEPT:
- There is a large increase in hydrophilicity.
3. Which of the following is often conjugated to xenobiotics during phase II
biotransformations?
- sulfate group.
4. Which of the following is a true statement about the bio-transformation of
ethanol?
- Acetaldehyde is oxidized to acetic acid in the mitochondria by aldehyde
dehydrogenase.
5. Which of the following enzymes is responsible for the bio-transformation and
elimination of serotonin?
- monoamine oxidase.
6. Which of the following reactions would likely NOT be catalyzed by cytochrome
P450?
- ester cleavage.
7. All of the following statements regarding cytochrome P450 are true EXCEPT:
- Increased activity of cytochrome P450 always slows the rate of xenobiotic
activation.
8. Which of the following statements regarding phase II bio-transformation
(conjugation) reactions is true?
- Phase II reactions greatly increase the hydrophilicity of the xenobiotic.
9. Where do most phase II biotransformations take place?
- cytoplasm.
10. Which of the following is not an important cosubstrate for phase II
biotransformation reactions?
- N-nitrosodiethylamine.
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