Complete Lecture series - Notes Organic Chemistry Practical
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Course
Organic Chemistry Practical (WBFA0565)
Institution
Rijksuniversiteit Groningen (RuG)
These documents are completely covering the lectures, along with explanation from the book which are necessary to know for the exam Organic Chemistry Practical.
spahybridized flatmolecule withoutrotation
at N Nrdoublebond
When weshinelightwitha certainwavelengthyou'll
givesomuchenergythat it wilflip Aftertheflip it won't
beflippedagainsincecis trans flipsbothhavedifferentwavelengths There is an energydifferencebetween
thetranscompound ciscompound that
youalready alsoknowthat cis is higherinenergyandslowly
will fallbacktotrans
Seekingstericdashintrans
Äii iii
iii
iii i
Moleculesshould
fit into a pocketofanothermoleculeofinterest Itshouldhavetherightshapeofcis trans
Withthismethodyouhavethepossibilityofactivatingdrugsinbodypartsofinterest You'llhavetotakethemedicine
and then activateit byshininglight to the particularbodyspot Deactivating also is possible
, Organic Chemistry Practical
Series 1 Introduction conjugation aromaticity
paracetamol impurities synthesis ofdiclofenac
1 Introduction
Drawing bonds
CC SCC
every singlebondhereis C C 0 bond
every double bond
here is EC a bond ÊÊ
Drawing reactions
Nu Ä Important isthat
youdraw onestepat a time
Thereactionisalwaysfromthe
electronsofthenucleophile
this carbonylis electrophilic bethe oxygenpulls e towardsitselfaway
his iselectrophilic
fromthecarbonThismakes a dipolemoment partiallynegative up and partially
positive down
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