Class notes
Cardiovascular System 8: Tissue Fluid & Oedema
- Course
- Institution
A detailed summary on the causes of oedema and the use of the reflection coefficient.
[Show more]
Seller
Follow
harrykane
Reviews received
Content preview
TISSUE FLUID & OEDEMAOedema (dropsy) = Increase in fluid in extracellular spaces of tissue.
Extracellular fluid volume is largely dependent on total amount of Na+ in ECF compartment;
therefore, need to regulate Na+.
Tissue fluid is mainly produced in capillaries (microcirculation). Blood pressure coming into
the microcirculation is controlled by metabolic factors and sympathetic nervous system.
Capillary = approx. 6 micrometres in diameter. Capillary also has a single layer of permeable
endothelium.
3 TYPES OF CAPILLARY:
1. Continuous Capillary
Most common type of capillary.
Have tight junctions (held closely together).
Limiting factor = contains pores and size of pores limits the size of substance
coming through.
2. Fenestrated Capillary
Contain large pores.
No tight junctions and more permeable than continuous capillary.
Therefore, because of these features, found in kidney and gut for larger
molecules to get through.
3. Sinusoid Capillary (Discontinuous)
Wide spaces and allow proteins/RBC’s to pass through.
Found in the liver and spleen.
In terms of least leaky to most leaky: Continuous capillary < Fenestrated capillary < Sinusoid
capillary.
Solute permeability = dependent on pore size.
Plasma proteins can’t cross capillary wall.
Some solutes pass through endothelial cells (lipid solutes) whereas, some solutes pass
between endothelial cells via pores (Na+, K+, glucose and amino acids). However, pores are
quite small so limits rate and size of molecules that can get through.
Fluid flows in a unidirectional manor across the capillary wall.
Fluid flow from plasma to interstitial space is known as ultrafiltration.
Fluid flow from interstitial space to plasma is known as reabsorption.
Hydrostatic pressure = drives water out of capillaries.
Osmotic pressure = opposes hydrostatic pressure to do with solutes and drives water to a
high solute concentration.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller harrykane. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.90. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
64438 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now