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Summary Resting Potential, Graded Potential, Action Potential

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Resting, Graded and Action Potential notes for first year university students. Includes: - Resting Membrane Potential : - Key Terms and definitions - What causes cell membranes to be charged and processes. - Graded Potential: - Definitions and processes - Summation of Postsyna...

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  • February 5, 2023
  • 11
  • 2022/2023
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Resting Potential, Graded Potential, Action Potential

Neurons get information from DENDRITES and CELL BODY

- They are connected to a lot of other neurons

- Based on summation of that information, neurotransmitters will either fire an

action potential or not.

Three types of potentials:

- Resting Potential:

o Resting potential of a neuron at rest

- Graded Potential:
o Based on stimulus potential neuron is going to get

- Action Potential:

o Can lead to synaptic activity on the next neuron


Resting Membrane Potential

Cell Membranes – composed of a phospholipid bilayer:

- Hydrophobic tail

- Hydrophilic head




In an aqueous environment, lipids arrange themselves in a double layer so that tails

are “inside” away from aqueous environment and heads are facing out, towards the
EXTRACELLULAR and INTRACELLULAR environments.

, Key Terms:

Cation – positively charged ion

- K+, Ca++, Na+

Anion – negatively charged ion

- Proteins-, Cl-, PO4-3

Electrical Gradient – gradients based on charge

Chemical Gradient – gradients based on concentration

Ions that play a major role in resting membrane potential includes, K+ and Na+

- Concentration of Na+ is higher in the EXTRACELLULAR region of the cell
- Concentration of K+ is higher in the INTRACELLULAR region of the cell

There are anions in both the extra- and intracellular regions of the cell, these usually

have a minimal effect,

- Except for the LARGE PROTEINS, which are negatively charged

Cell membranes are polarized (charged)

What causes cell membranes to be charged?

All cell membranes have a slight voltage or potential difference across their expands.

- Extracellular – slightly positive

- Intracellular – slightly negative

o Caused by the selective diffusion of the ions across the membrane

Transmembrane protein – CHANNEL PROTEIN – only allow one type of particle to
diffuse through them

- We are interested in the K+ and Na+ Channels
o These channels allow charged ions to move along their concentration
gradients through FACILITATED DIFFUSION

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