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H3_Antipsychotica
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AntipsychoticaMajeure tranquillisers
• Conventionele antipsychotica
(neuroleptica)
- Fenothiazinen & thioxanthenen
- Butyrofenonen & difenylpiperidinen
- Benzamides
• Nieuwere atypische antipsychotica
1.
2. Deze atypische hebben een ander werkingsmechanisme
1. Schizofrenie
Schizofrenie
Schizofrenie (0.5-1% van de bevolking) = meest voorkomende vorm van
psychose
- Verlies van perceptie van de werkelijkheid, patiënt leeft in zijn eigen
wereld
- Sterk genetische component
- Type I of positieve symptomen
Wanen (foute overtuigingen tgv onjuiste gevolgtrekking)
Hallucinaties (zintuiglijk, vnl auditieve)
- Type II of negatieve symptomen
Afgevlakt/afgestompt affect
Anhedonie = onvermogen om genot te ervaren
Alogie
Gebrek aan wilskracht
Sociale isolatie
- Cognitieve stoornissen; Angst; Depressie; Agressie
Dit is een redelijk hoog percentage, maar hier zitten wel gradaties in (niet alle mensen hebben alle
symptomen in de hoogste graad van een psychotische stoornis). Er zijn ook Pt die ambulatie Th
krijgen en nog goed kunnen functioneren
Positieve symptomen : symptomen die erbij komen
Negatieve symptomen: dingen die mensen normaal wel moeten hebben, maar die zijn weggevallen
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