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Samenvatting ziektebeelden cluster PMP $11.21   Add to cart

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Samenvatting ziektebeelden cluster PMP

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Samenvatting van alle ziektebeelden behandeld in cluster psychomedische problemen, inclusief neurobiologie. Alles wat je nodig hebt voor de schriftelijke neurobiologie toets en de KRIP mondeling.

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  • February 11, 2023
  • 256
  • 2022/2023
  • Summary
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Delier & Dementie

,ALGEMEEN

,Genetische kwetsbaarheid Alzheimer
● Early onset AD: 30-60 jaar <10% van de mensen met Alzheimer
● Late onset AD: Apoe E gen verhoogt risico, maar niet zeker dat je dan Alzheimer krijgt (4-8x zo groot)
● Familiaire AD: Mutaties in amyloid precursor protein (APP), presenilin-1 (PS1) en presenilin-2 (PS2)
genen. (Kans op overerving 40%)



● Alle AD patiënten ontwikkelen de kenmerkende neuropathische laesies
○ Tau-tangles
○ Aß-plaques

, Schalen en tests voor cognitieve stoornis bij
dementie
Cognitieve screeningstesten:

● Mini Mental State Exam (MMSE) → screening waarmee globale indruk van cognitief functioneren verkregen wordt. 7 categoriën,
met 30 punten totaal. Kan wel beïnvloed worden door opleidingsniveau.
● Cognitieve Screening Test (CST) → korte vragenlijst over oriëntatie en geheugen (beperkt onderzocht, alleen in NL)
● Seven Minute Screen (7MS) → 4 subsets: tijdsoriëntatie, leertest, kloktekentest en woordfluency

Cognitieve schalen

● Clinical dementia Rating Scale (CDR) → goudenstandaard voor ernst dementie,
● Global deterioration Scale (GDS) en Functional Assessment Stating (FAST) → Bij gevorderde dementie beoordeling achteruigang.
GDS beschrijft 7 stadia, FAST substadia
● Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) → 6 Items dat door een familielid/verzorgende wordt
ingevuld als heteroanamnese
● Delirium Observatie Screening SChaal (DOS) → voor herkenning en ernst delier

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