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Ulcerative Colitis & Crohn’s - GI system
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A summary of Ulcerative Colitis & Crohn’s disease. Including classification and treatment options.
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Ulcerative Colitis & Crohn’sUlcerative Colitis
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that causes
inflammation and ulcers in the colon. The main symptom of active disease is
diarrhoea mixed with blood.
On examination may have: clubbing, abdominal tenderness, anaemia, fever etc.
Treatment:
Steroids
CiA/ infliximab (monoclonal antibody against TNF-α)
Surgery
Azathioprine (immunosuppressive)
After surgery ileoanal pouches are sometimes created over a stoma
Also systemic effecting the yes skin and liver.
Crohn’s Disease
Crohn’s disease is a type of inflammatory bowel disease (IBD) that may affect
any part of the gastrointestinal tract from mouth to anus. It’s characterised by
patchy inflammation with ulceration.
Symptoms often include abdominal pain, diarrhoea (which may be bloody if
inflammation is severe), fever, and weight loss.
Bacterial Abnormalities:
Loss of some Firmicutes and Bacteroides
A role for adherent invasive E. coli
BUT this does not explain everything: Crohn’s disease is not transmittable,
and does not account for familial risk
Mucous layer is thicker in CD patients but thinner in UC patients
CD patients have abnormal permeability due to tight junction defects.
Autophagy: cells undergo partial autodigestion:
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