BIOPHARMACEUTICS ALL POSSIBLE QUESTIONS AND ANSWERS 2023 GRADED A
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BIOPHARMACEUTICS
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BIOPHARMACEUTICS
BIOPHARMACEUTICS ALL POSSIBLE QUESTIONS AND ANSWERS 2023 GRADED A
In LADMER system, L stands for liberation as the first step which determines the following aspects, except:
a. onset of action c. rate of absorption
b. type of preparation d. bioavailability
b. type of preparation
The ultimate...
biopharmaceutics all possible questions and answers 2023 graded a in ladmer system
l stands for liberation as the first step which determines the following aspects
except a onset of action c rat
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BIOPHARMACEUTICS ALL POSSIBLE QUESTIONS
AND ANSWERS 2023 GRADED A
In LADMER system, L stands for liberation as the first step which determines the
following aspects, except:
a. onset of action c. rate of absorption
b. type of preparation d. bioavailability
b. type of preparation
The ultimate evaluation of dosage forms or delivery system is in:
a. disintegration time c. clinical effectiveness
b. thickness d. taste
c. clinical effectiveness
Factor that contributes to patient's difference in drug concentration in the body, except:
a. body weight c. age
b. obesity d. climate
d. climate
A rate limiting factor in the dissolution of drugs is:
a. disintegration of the tablet
b. thickness
c. content uniformity
d. local effect
a. disintegration of the tablet
The effect of reduced particle size of a drug is:
a. increased absorption c. increased hardness
b. increased disintegration d. all of them
a. increased absorption
A cause of patient to patient variability of time course of the drug in the plasma is:
a. disease c. genetic in origin
b. concomitant drug therapy d. all of the above
d. all of the above
Dissolution rate tests can be used to predict bioavailability if:
a. dissolved drug remains free in the GIT
b. dissolved drug is decomposed in the GIT
c. drug is hydrolyzed in the GIT
d. all of them
a. dissolved drug remains free in the GIT
Elimination half-life of a drug is the time in hours needed to reduce drug concentration
to:
a. half of the parent drug c. all or taken dose
b. one fourth of the initial dose d. a & b
a. half of the parent drug
Tmax means:
a. time of great solubility of the drug c. time of peak concentration
b. peak height concentration d. AUC values
c. time of peak concentration
,To generally increase the solubility of a poorly soluble drug in an aqueous medium, the
process is:
a. complexation c. prepare into a derivative
b. adsorption d. a & c
d. a & c
The ionization constant of a drug is important in bioavailability since it determines the
following, except:
a. its aqueous solubility c. pH of the medium
b. dissolution rate d. extent of protein binding
d. extent of protein binding
The difference in bioavailability of a drug product of the same therapeutic agent is due
to:
a. difference in formulation ingredients
b. difference in packaging
c. difference in methods of manufacture
d. a & c
d. a & c
Which of the crystal forms give the best dissolution rate?
a. meta-stable polymorph c. stable polymorph
b. amorphous d. a and b
b. amorphous
The termination of action of a drug is determined by:
a. excretion of intact active molecule c. tissue redistribution
b. excretion of active molecule d. a & c
d. a & c
Pharmaceutical equivalents are drug products that contain:
a. identical amounts of active drugs
b. identical amounts of inactive ingredients
c. identical amounts of excipients
d. all of the above
d. all of the above
The purpose of biotransformation reaction is:
a. deactivate the drug
b. preserve the drug from destruction
c. promote elimination of inactive drug
d. a & c
d. a & c
The advantage of sublingual/buccal administration is:
a. no occurrence of gastrointestinal degradation
b. drug directly in the circulation
c. not pass to the liver
d. a & c
d. a & c
The integral of the drug level over time from zero to infinity is:
a. biologic half-life c. bioavailability
b. area under the curve d. biopharmaceutics
,b. area under the curve
The rate and extent at which the drug appears in the bloodstream is known as:
a. biopharmaceutics c. bioavailability
b. area under the curve d. biologic half-life
c. bioavailability
An inactive or much less active substance which is transformed to active drug in the
body is:
a. dosage form c. asp
b. drug product d. prodrug
d. prodrug
A site in the biophase to which drug molecules can be found is:
a. fluid compartment c. receptor
b. unit membrane d. none of the above
c. receptor
A branch of science which deals with physical and chemical properties of drug
substance, the dosage form, and the biological effectiveness of a drug product upon
administration is:
a. pharmacology c. biopharmaceutics
b. pharmacokinetics d. pharmacy
c. biopharmaceutics
The dose size required maintaining effectiveness or therapeutic concentration according
to dosage regimen is:
a. priming dose c. loading dose
b. maintenance dose d. any of the above
b. maintenance dose
The ability of the substance to exist in different crystalline forms is: a. amphoterism c.
polymorphism
b. sating in d. precipitation
c. polymorphism
Differences in bioavailability are most frequently observed with drugs are administered
by which of the ff. routes?
a. subcutaneous c. oral
b. intravenous d. sublingual
c. oral
A drug can exert its pharmacologic effect only when it is:
a. protein bound c. free drug
b. protein unbound d. b & c
d. b & c
Which of the following factors delays transit time?
a. increasing viscosity c. water
b. liquid diet d. b & c
a. increasing viscosity
The principal site of drug metabolism is:
a. kidney c. gut wall
b. muscle tissue d. liver
d. liver
, The mechanism for drug excretion via the kidney is:
a. facilitated diffusion c. pinocystosis
b. glomerular filtration d. ion transport
b. glomerular filtration
The major plasma protein involved in the distribution of weak acids is: a. albumin c.
glycine
b. glycoprotein d. gelatin
a. albumin
For faster absorption, what type of diluent or filler is needed if the drug is hydrophobic?
a. hydrophilic c. amphilic
b. water repellant d. b & c
c. amphilic
The route of administration which will be by-pass the GIT degradation and hepatic
metabolism is:
a. intravenous injection c. buccal
b. sublingual d. b & c
d. b & c
A branch of science which deals with the changes of drug concentration and its
metabolites in the human or animal body after administration is:
a. bioavailability c. biopharmaceutics
b. pharmacokinetics d. a & b
b. pharmacokinetics
The first step which determines the onset of action, rate of absorption, availability is:
a. liberation c. excretion
b. distribution d. absorption
a. liberation
Liberation is a process controlled by:
a. age of the patient c. both a & b
b. characteristic of the drug d. none of the above
b. characteristic of the drug
Which is the following factors affect the dissolution in the lipid membrane of the lipid
soluble unionized fluid compartment:
a. pH c. lipid/water partition coefficient
b. pKa d. all of the above
d. all of the above
Those multiple source drug products that contains identical amount o the identical
active ingredients in identical dose forms are called: a. chemical equivalents d.
pharmaceutical alternates
b. biological equivalents e. therapeutic alternates
c. therapeutic equivalents
a. chemical equivalents
When considering drug transport, 'a passive transport process' implies that:
a. all of the drug will pass from one compartment to another
b. the process requires energy
c. The net transfer of drug is from an area of high concentration to an area low
concentration
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