Histologie van de lymfoïde organen
Primaire lymfoïde organen: beenmerg (paratrabeculair)
Rood beenmerg
Geel beenmerg
Hematopoiese: pluripotente stamcel multipotente stamcel
- Lymfoïde voorlopercellen
B/T- lymfocyten
- Myeloïde voorlopercellen
Granulocyten/monocyten/RBC/megakaryocyten
- Cytokines/GF
o G-CSF = neupogen = filgrastim
Stroma
- Reticulumcellen
- Reticulinevezels = coll III + extracellulaire matrixcomponenten
- Vetcellen
Vasculaire sinusoïden
- Gedilateerde capillairen
- Discontinu endotheel + bm
Hematopoietische cellen
- Ertythropoiese
o Pro-erythroblast basofiele erythroblast polychromatofiele erythroblast
orthochromatofiele erythroblast reticulocyt erythrocyt
o Afname celvolume en nucl volume (pyknotisch)
o Eu => heterochromatine
o Afname RNA
o Toename hemoglobine
o Organellen verdwijnen
o Erythropoietine
- Granulopoiese: 10-14d
o Myeloblast promyelocyt myelocyt metamyelocyte ( staaf) granulocyt
Neutrofiele
Eosinofiele
Basofiele
o Grote kern + 1-3 nucleolen + basofiel cytoplasma
o Eu => chromatine
o Azurofiele granulen: lysosomen + myeloperoxidase
o G(M)-CSF
o Granulopoietisch compartiment/stapeling mature cellen in beenmerg/circ
populatie/marginerende populatie
- Maturatie monocyten
o Monoblast promonocyt monocyt
o RER + Golgi + vacuoles + azurofiele granules
1
, o Direct in bloedbaan
o Weefsels: macrofagen
- Maturatie lymfocyten
o Lymfoblasten in beenmerg
o thymus: T-lymfocyten
o beenmerg: B-lymfocyten
o Sec lymfoïde organen
- Vorming bloedplaatjes
o Megakaryoblast promegakaryocyt megakaryocyt (oiv thrombopoietine)
o Polyploïd (8N => 64N)
o Proplatelets: bloedplaatjes aan sinusoïden
Medische toepassingen
- Aplastische anemie
- MDS: myelodyspastisch syndroom
o Celarm beenmerg
o Pancytopenie
- AML: acute myeloïde leukemie
o Celrijk beenmerg
o Verminderde maturatie
o Pancytopenie
- ALL: acute lymfoblastenleukemie
Primaire lymfoïde organen: thymus
- Endoderm: 3e kieuwzakje
- Lymfo-epitheliaal orgaan
o Epitheelcellen stervormig
o Lymfoïde cellen: thymocyten
- Bw kapsel + septa => lobuli
Cortex
- donker
- cTEC’s: reticualire epitheelcellen
o uitlopers verb via desmosomen
o MHCI/II
o euchromatine
- thymocyten
o TdT pos lymfoblasten
- kernpuinmacrofagen
Medulla
- helder
- mTEC’s: reticulaire epitheelcellen
o uitlopers verb via desmosomen
- thymocyten
o TdT neg kleine lymfocyten (afk van cortex)
- dendritische cellen
2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller bronywiedeman. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $5.97. You're not tied to anything after your purchase.