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Summary Autonomic Nervous System pharmacology drug table
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  • Course
  • Pharmacology
  • Institution
  • University Of The Witwatersrand (wits)
  • Book
  • Basic and Clinical Pharmacology 15e

Introducing the ultimate study notes for pharmacology students and medical professionals, focused on the autonomic nervous system! Our comprehensive and organized drug chart contains everything you need to know about the various drugs used in the autonomic nervous system. Presented in an easy-to...

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  • No
  • 6-10
  • February 28, 2023
  • 1
  • 2022/2023
  • Summary

Subjects

  • ans
  • ans drugs
  • ans pharmacology
  • ans drug chart
  • sympathomimetics
  • sympatholytics
  • parasympathomimetics
  • parasympatholytics
  • autonomic nervous system
  • autonomic nervous system drugs
  • autonomic nervous system p

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  • University of the Witwatersrand (wits)
  • Pharmacology
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Autonomic Nervous System

DRUGS MOA INDICATIONS S/E
Blurred vision, painful eye, night

Parasympathomimetics
Pilocarpine Muscarinic agonist Glaucoma
blindness
Reversal of neuromuscular blockade
Neostigmine Diarrhoea, increased salivation &
Myasthenia gravis
sweating, abdominal cramps,
Pyridostigmine Reversible AchE inhibitor Chronic myasthenia gravis
bradycardia
Edrophonium Diagnosis of myasthenia gravis
Tacrine, donepezil, Tacrine: hepatotoxicity, Others: GI
Alzheimer's disease
rivastigmine, galantamine distress
sickness
Motion




Prevention of motion sickness, postop
Scopolamine xerostomia, sedation, delirium
nausea & vomiting, reduces vertigo


Hyoscine Butylbromide
Reduces smooth muscle and secretory dry mouth, tachycardia, confusion,
GIT




Dicyclomine
activity of gut, IBS antispasmodic urinary ret., intraocular pressure oral
Mebeverine
Decrease salivary & bronchial
Respiratory Secretory




Glycopyrrolate secretions, Relax bronchial smooth COPD maintenance
Parasympathetic Nervous System




muscle
Ipratropium bromide
Tiotropium Relaxes bronchial smooth muscle,
Xerostomia
asthma COPD
Glycopyrrolate
Parasympatholytics




Causes mydriasis & cycloplegia, Retinal
Cholinergic Ophthalmolog




Atropine
exam
Antimuscarinics increased intraocular pressure in
Tropicamide
y




(anticholinergic) Produce Mydriasis and cycloplegia closed angle glaucoma
Cyclopentolate prior to refraction, Eye exam
poisoning




Blocks muscarinic excess at exocrine
glands, heart, smooth muscle, Antidote
in organophosphate poisoning
dilated pupils, warm, dry skin,
Atropine Counteracts vagal effects during tachycardia, tremor, ataxia, delirium,
anaesthesia, Counteracts muscarinic and coma
activity of neuromuscular blockers
CNS




(NMB), Premed, Reversal NMB,
Anaesthesia
Trihexyphenidyl dizziness or blurred vision, dry
Improves tremor, Parkinson's
Biperiden mouth,upset stomach, vomiting,
Oxybutynin
agonist Acting incontinence
Autonomic Nervous System




Darifenacin
Urinary




Reduces detrusor muscle tone, spasms, dry mouth (xerostomia),
Solifenacin
Enuresis (overactive bladder) palpitations, constipation, confusion
Tolterodine
Propiverine
Anaphylaxis, In local anaesthetic incr. N,V headache, Prolonged use:
adrenergic Direct




Epinephrine/ adrenaline α1 α2 agonist β1 β2 agonist
doa peripheral vasoconstriction
Immediate metabolic
precursor of NE. α and β Treat shock, Severe heart failure, Acute
Dopamine Nausea, HT, arrythmias
agonist D1 and D2 agonist hypotension
(dopaminergic)

Dobutamine β1agonist Acute heart failure (MI) Atrial fibrillation
Direct Acting
Sympathomimetics




Salbutamol Short acting β2agonist Restlessness, tremor, tachycardia or
Asthma
arrythmia
Salmeterol Long acting β2agonist
Phenylephrine α1agonist Nasal congestion, hypotension HT, headache
Release stored NE from
Mixed Acting




Ephedrine nerve endings α and β Tacrine: hepatotoxicity, Others: GI
Treat hypotension
agonist distress
Etilefrine
Pseudoephedrine α and β agonist
Nasal congestion CNS stim, HT
Phenylpropanolamine
Sympathetic Nervous System




Central
Acting




Alphamethyl dopa Central α 2 agonist Hypertension in pregnancy Sedation, hyperprolactinaemia



Pheochromocytoma (Pre op), Raynaud Postural hypotension, nasal
α-adrenoreceptor blocking agents




Phenoxybenzamine Non-selective
disease stuffiness, N&V, decr ejaculation



Pheochromocytoma, HPT crisis, (MAO I Postural hypotension, arrhythmias,
Phentolamine α1 + α2
tyramine food, clonidine withdrawal) angina pain
Postural hypotension, drowsiness,
Prazosin, terazosin, Hypertension, BPH (benign prostatic
Selective α1 headache, nasal congestion,
Sympatholytics




doxazosin Hypertrophy)
Retrograde ejaculation
Postural hypotension, drowsiness,
Tamsulosin, alfuzosin Selective α1A BPH (benign prostatic Hypertrophy) headache, nasal congestion, Floppy
iris syndrome
Hypertension, migraine,
β-adrenoceptor Blockers




Propranolol hyperthyroidism, Angina pectoris,
β1 , β2
Myocardial infarction
Bronchospasm, Bradycardia, Heart
Timolol Glaucoma, Hypertension block/failure, Fatigue, Impotence in
Atenolol, Bisoprolol , Hypertension, Angina, Myocardial males, Hypoglycaemia, Cold
Esmolol, Metoprolol β1 infarction(a) extremities, Vivid dreams
Nebivolol Hypertension
Hypertension, non-acute congestive
Carvedilol, Labetalol β1 , β2, α 1
Heart failure

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