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Antianginal Drugs Pharmacology
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ANTIANGINAL DRUGS PHARMACOLOGY DR NAJEEB NOTES
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Angina is a central chest discomfort or pain which may be just like pressing pain or weight likediscomfort or band like discomfort on the chest or like a heavy weight like a band or a burning
sensation. Angina should not last or does not last classically by more than 20 minutes. If severe
chest ischemia lasts more than that, it will lead to myocardial infarction. In China, classical
angina classical Indiana is also called typical angina. Classical Indiana and classical Indiana are
also known as "typical angina" and another name for the same situation is "exertional angina
desertional" in China, it has a special type of pathophysiology under it. This type of angina is
always precipitated by exertion or emotional upsides right and usually relieved by taking rest.
The myocardium which is more near to the endocardium this is the deepest mycardium is that
right and this is subendocardial. The inner most zone is the innermost layer of the inner most
zone of the heart. During even a normal heart, the outer is better perfused and inner myocardia
is poorly perfused.
Prince Madame Jayana explains the pathophysiology of unstable angina and stable angina.
This type of angina is mainly due to coronary artery plasticity, either with a little bit of
atheroseclerotic lean or with no astrological layer. That is real problem, is that coronary artery
has fluctuating tone. There is unstable coronary plaque, the astrometers plaque, and coronary
artery is unstable. Plaque with super added thrombus is a dynamic obstruction. Platelets will
stick on it just like platelet adhesion and platelet aggregation. Unstable angina is so unstable
that if it's not managed well, within 20 minutes or 30 minutes it may fall to the category of
myocardial infarction. That's clear right? This type of angina by definition is very sphere in China.
To reduce the workload of the myocardium and achieve symptom relief, the best therapy is to
reduce oxygen demand to equal oxygen supply. Drugs that reduce oxygen demand include
foreign and nitrates. Coronary weather dilators (dilators that are placed in the coronary arteries
during an angina attack) are also effective in relieving symptoms. In stable angina, atromatous
plaque is stable but it can be easily dilated with drugs. However, in the long run, managing these
patients for atherosclerosis prevention is important. Smoking cessation, good diabetes
management, and maintaining a healthy weight are all important factors. In this patient, there
are four key strategies to manage: first, give medications that disperse platelets; second,
provide antiplatelet agents; third, thrombolytic drugs; and fourth, coronary weather dilators.
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