NBME 16 Block 1 and 2 (Answered) Verified Solution

NBME 16 Block 1 and 2 (Answered) Verified Solution Lab values in Sarcoidosis 1.Elevated ACE levels- from granuloma 2.Elevated CD4/CD8 counts in BAL. 3.High Calcium 4.HIGH 1,25 DIHYDROXYCHOLICALCIFEROL (Due to increased production of 1 alpha hydroxylase that converts Vit D to its active form -nbme) 5. Low PTH Histology of Sarcoidosis : 1.Epithelioid granuloma - Granuloma with foreign body giant cells (means Giant cells with disorganized nuclei) Type 4 HSN. 2.Asteroid body - Star shaped giant cell cytoplasmic inclusion - collection of Lipid 3. Schwmann bodies - Calcificatins - collections of Calcium and protein. Causes of erythema nodosum NODOSUM NO- No cause Idipathic 60% cases D - Drugs Sulfa, Iodide O -OCP S -Sarcoidosis U - UC/CHRONS M- Microbiota - TB,Leprosy, Streptococcus, Yersinia, Histoplasma. Erythema nodosum abd sarcoidosis Most common non specific manifestation in sarcoidosis. Painful, Bilateral. MC organism causing Acute Prostatitis in OLD E.Coli. IN Young - Chlamydia, Gono. Causes of raised CK 1. Hypothyroid myopathy 2. Inflammatory myositis 3. Statin induced Normal CK 1.Polymyalgia Rheumatica 2. Steroid induced Myopathy 3. vit D deficiency Myopathy Polymyositis / Dermato lab values Raised CK, Rasied Aldolase, +ANA +Anti Jo-1