Samenvatting van het minisymposium van de cursus Weefsels (BMW10705)
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Course
Weefsels (BMW10705)
Institution
Universiteit Utrecht (UU)
Deze gedetailleerde samenvatting behandelt alles wat aan bod is gekomen tijdens het minisymposium van de cursus Weefsels aan de Universiteit Utrecht (BMW10705).
,Inhoudsopgave
1. Antistoffen in onderzoek....................................................................................................................3
Monoklonaal en polyklonaal..............................................................................................................3
Immunoassay......................................................................................................................................3
Immunoprecipitatie en immuno-affiniteitschromatografie................................................................3
Western Blot en SDS-PAGE.............................................................................................................4
Cytokine bead assay...........................................................................................................................5
Immunohistochemie...........................................................................................................................5
Antigeen-antilichaam interactie.........................................................................................................6
2. Aantonen van antistoffen...................................................................................................................7
Inleiding..............................................................................................................................................7
Diagnose technieken..........................................................................................................................7
ELISA...................................................................................................................................................7
Indirecte methode..........................................................................................................................8
Competitieve methode...................................................................................................................8
Double antigen methode................................................................................................................8
Diagnose.............................................................................................................................................9
PCR...............................................................................................................................................10
3. Ziekmakende antistoffen deel 1.......................................................................................................11
Klinische presentatie en histologie...................................................................................................11
Pathofysiologie.................................................................................................................................11
Antilichamen op zich kunnen de ziekte veroorzaken....................................................................12
Desmogleïne compensatie model.................................................................................................12
Dsg nonassembly depletion..........................................................................................................13
T-cellen.........................................................................................................................................13
Pemphigus antilichamen..............................................................................................................13
Medicijnen........................................................................................................................................14
Prednison......................................................................................................................................14
Immuun onderdrukkende medicijnen..........................................................................................14
Rituximab......................................................................................................................................14
4. Ziekmakende antistoffen deel 2.......................................................................................................15
IgE-verwante chronische ziekten......................................................................................................15
Omalizumab.....................................................................................................................................15
Omalizumab bij astma..................................................................................................................16
5. Genezende antistoffen deel 1...........................................................................................................17
1
, Mechanismen voor het doden van tumoren....................................................................................17
Directe doding van tumorcellen...................................................................................................17
Immuungemedieerde celdoding...................................................................................................17
Vasculaire en stromale ablatie......................................................................................................18
Ontwikkeling van antilichamen........................................................................................................18
Immuunreactie.................................................................................................................................19
6. Genezende antistoffen deel 2...........................................................................................................19
Reumatoïde Artritis (RA)...................................................................................................................19
Medicijnen voor RA..........................................................................................................................20
Biologics........................................................................................................................................20
Tumor necrose factor remmers (TNF-remmers)...........................................................................21
Interleukine-6 remming................................................................................................................22
B-cel modulatie.............................................................................................................................22
T-cel modulatie.............................................................................................................................22
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