18 Principles of Pharmacology - Antidepressants and Sedatives
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Course
Pharmacology
Institution
Pharmacology
The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry, and physiology as to the mechanisms of drug action, biodistribution and metabolis...
Harvard-MIT Division of Health Sciences and Technology
HST.151: Principles of Pharmocology
Instructor: Dr. David Standaert
Antidepressants and
Sedatives
David G. Standaert, M.D., Ph.D.
Massachusetts General Hospital
Harvard Medical School
,Depression
A frequent problem, affecting up to
5% of the population
Common presentations include low
mood, loss of energy, disinterest in
activities
May also include weight loss, sleep
disturbance, or psychosis
Should be considered in patients with
atypical dementia and chronic pain
, A stricter standard for the
diagnosis of depression - DSM-IV
Five of the following present during the same 2-week period and
represent a change from previous functioning:
– depressed mood
– markedly diminished interest or pleasure in all, or almost all, activities
– significant weight loss when not dieting or weight gain
– insomnia or hypersomnia
– psychomotor agitation or retardation
– fatigue or loss of energy
– feelings of worthlessness or excessive or inappropriate guilt
– diminished ability to think or concentrate, or indecisiveness
– recurrent thoughts of death, recurrent suicidal ideation or a suicide attempt
The symptoms cause clinically significant distress or impairment in
social, occupational, or other important areas of functioning.
The symptoms are not due to the direct physiological effects of a
substance (e.g., a drug of abuse, a medication) or a general
medical condition (e.g., hypothyroidism).
The symptoms are not better accounted for by Bereavement
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