NR 283 Final Exam Review Chamberlain 5 star rated

NR 283 Final Exam Review Chamberlain 5 star rated Osetoporosis - Decreased Bone Mineral Density Osteoporosis Pathophysiology - Bone remodeling leads to increased bone reabsorption, leads to decreased bone formation causing thin fragile bones leading to fractures. Increased osteoclast activity and decreased osteoblast activity. Risk factors for Osteoporosis - 1. Postmenopausal women 2. Aging 3. Sedentary Lifestyle 4. Hyperthyroidism 5. Smoking Rheumatoid Arthritis - Autoimmune disorder causing chronic systemic inflammation Pathophysiology Rheumatoid Arthritis - 1. Neutrophils degrade surface layer of cartilage 2. Inflammatory cytokines breakdown cartilage & bone 3. T-Cells cause fibroblasts to turn into a thick abnormal layer of tissue 4. Inflammation is constant & spreads to ALL synovial joints Difference between Osteoarthritis & Rheumatoid Arthritis - Osteoarthritis is a degenerative condition due to "wear and tear" cartilage breaks down causing stiff joints and pain.