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Samenvatting Zwangerschap
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samenvatting van het thema zwangerschap van het vak moeder en kind
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Internationale casuïstiek 2: moeder en kindZwangerschap
Inleiding
Om zwangerschap te begrijpen aandacht voor menstruele cyclus
Cyclus van 28 dagen
Enerzijds hormonaal
- 3 niveaus
o Hypothalamus
GnRH (Gonadotropine Releasing Hormone)
o Hypofyse
Oiv GnRH:
FSH (Follikel Stimulating Hormone)
LH (Luteïniserend Hormoon)
o Ovaria (eierstokken)
Oestrogeen
Inhibine
Progesteron
Anderzijds endometrium (=baarmoederslijmvlies
Hypofysaire controle van de ovulatie:
Aan het begin van de menstruele cyclus lage oestrogeenconcentraties in bloed.
Lage oestrogeenconcentraties in bloed stimulatie van FSH – productie.
,Stijgende FSH – productie stimulatie van de groei van follikels.
Door de groei van follikels en oestrogeenproductie negatieve terugkoppeling naar FSH.
Op welke manier gebeurt de negatieve
terugkoppeling naar FSH?
Follikels groeien productie van oestrogeen
(oestradiol) stijgt door interactie van granulosa – en
thecacellen in follikel. Eveneens in granulocellen van
follikels productie van inhibine (B) glycoproteïne
dat afgifte van FSH remt.
, Door negatieve terugkoppeling naar FSH daling FSH in bloed.
Door daling FSH concentratie in bloed slechts 1 follikel komt tot rijping (dominante follikel met
meeste FSH – receptoren).
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