armacologia renal
Diureticos:
Diureticos de tubulo contorneado proximal
Diureticos de ASA
Diureticos Tiazidicos
Diureticos ahorradores de K (potasio)
Trastornos electroliticos
Inhibidores del sistema Renina- Angiotensina-Aldosterona
inhibidores del sistema renina angiotensina aldoster
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Intec
Farmacologia
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J-INCOG
FARMACOLOGÍA
, J-INCOG
FARMACOLOGÍA RENAL
DIURETICOS
- Incrementan diuresis (volumen de orina). Disminuyen la reapsorción de Na+. Varían en eficacia.
Útiles para el manejo de edema e hipertensión arterial.
Sitio de acción; Diuréticos
Túbulo
– contorneado
HCO3
Glomérulo Na+ distal 2+
Túbulo 4 Ca
Na+
contorneado CI
–
Aferente 2
proximal
Eferente
1
Azúcares +
5
K
H2O Aminoácidos H
+
Na+
Ca
2+ + 5
2+
Na
Mg
Corteza
Médula 3
Na +
K+
–
2CI
1 Manitol Asa de Henle Asa de Henle
descendente ascendente
2 Acetazolamida
(permeable al agua) (permeable a sales)
3 Diuréticos de Asa
4 Diuréticos Tiazídicos
5 Ahorradores de K+ Ducto
colector
Asa de Henle
DIURÉTICOS DE TÚBULO CONTORNEADO PROXIMAL
Manitol
Usos Hipertensión intracraneal o intraocular; glaucoma. Sobredosis de drogas.
Diurético osmótico: ↑ la presión osmótica del filtrado glomerular. ↑ flujo de orina. ↓
Mecanismo
presión intracraneal/ intraocular
Efectos Edema pulmonar, deshidratación, hipo/hipernatremia, hipovolemia aguda.
secundarios Contraindicado en insuficiencia cardíaca congestiva y anuria.
Acetazolamida - Dorzolamida - Brinzolamida
Glaucoma, alkalosis metabólica, mal de montaña (alkalosis respiratoria y edema por
Usos
hipoxemia), hipertensión intracraneal idiopática.
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