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Farmacologia renal

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armacologia renal Diureticos: Diureticos de tubulo contorneado proximal Diureticos de ASA Diureticos Tiazidicos Diureticos ahorradores de K (potasio) Trastornos electroliticos Inhibidores del sistema Renina- Angiotensina-Aldosterona

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  • March 27, 2023
  • 5
  • 2022/2023
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J-INCOG




FARMACOLOGÍA

, J-INCOG

FARMACOLOGÍA RENAL
DIURETICOS

- Incrementan diuresis (volumen de orina). Disminuyen la reapsorción de Na+. Varían en eficacia.
Útiles para el manejo de edema e hipertensión arterial.
Sitio de acción; Diuréticos
Túbulo
– contorneado
HCO3
Glomérulo Na+ distal 2+
Túbulo 4 Ca
Na+
contorneado CI

Aferente 2
proximal

Eferente
1
Azúcares +
5
K
H2O Aminoácidos H
+

Na+



Ca
2+ + 5
2+
Na
Mg
Corteza

Médula 3
Na +
K+

2CI
1 Manitol Asa de Henle Asa de Henle
descendente ascendente
2 Acetazolamida
(permeable al agua) (permeable a sales)
3 Diuréticos de Asa
4 Diuréticos Tiazídicos
5 Ahorradores de K+ Ducto
colector



Asa de Henle



DIURÉTICOS DE TÚBULO CONTORNEADO PROXIMAL

Manitol

Usos Hipertensión intracraneal o intraocular; glaucoma. Sobredosis de drogas.

Diurético osmótico: ↑ la presión osmótica del filtrado glomerular. ↑ flujo de orina. ↓
Mecanismo
presión intracraneal/ intraocular

Efectos Edema pulmonar, deshidratación, hipo/hipernatremia, hipovolemia aguda.
secundarios Contraindicado en insuficiencia cardíaca congestiva y anuria.

Acetazolamida - Dorzolamida - Brinzolamida

Glaucoma, alkalosis metabólica, mal de montaña (alkalosis respiratoria y edema por
Usos
hipoxemia), hipertensión intracraneal idiopática.

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