Sumario Farmacos Anti-bacterianos, Antimicobacterianos, Anti protozoarios y Anti virales
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Course
Farmacologia
Institution
Intec
Farmacologia antimicrobioanos-Virus-Bacterias- Protozoas
Sintesis de lanosterol
Sintesis de la pared celular
Sintesis de acido nucleicos
Sintesis de ergosterol
Polienos
Triazoles
Imidazoles
Antimetbolito
Equinocandinas
Inhibidores de escualeno epoxidasa
Antivirales
Inhibidores desca...
SÍNTESIS DE LANOSTEROL SÍNTESIS DE LA PARED CELULAR
Echinocandinas
–
– Anidulafungina
Escualeno Caspofungina
Epoxidasa de Escualeno Micafungina
Epoxido de escualeno
INTEGRIDAD DE MEMBRANA CELULAR
SÍNTESIS DE ERGOSTEROL Lanosterol Polienos
Amphotericina B
14– –demetilasa Nistatina
Azoles Ergosterol
Clotrimazol
Fluconazol Ergosterol
Itraconazol SÍNTESIS DE ÁCIDOS NUCLÉICOS
Ketoconazol –
Miconazol –
Voriconazol Flucitosina
POLIENOS
Anfotericina B
Uso Micosis subcutáneas y sistémicas. Administración intravenosa lenta o inratecal.
Interactua con ergosterol formando poros en la membrana que permiten la fuga de
Mecanismo
electrolitos. El más amplio espectro de todos los agentes antifúngicos.
Uso Micosis cutáneas y candidiasis oral. Administración tópica.
Demasiado tóxico para uso sistémico. Interactua con ergosterol formando poros en
Mecanismo
la membrana que permiten la fuga de electrolitos.
TRIAZOLES
Fluconazol — Itraconazol — Voriconazol — Posaconazol — Isavuconazol
Micosis sistémicas locales y menos severas. Fluconazol para cádidiasis y
Uso
meningitis por criptococo. Voriconazol e Isavuconazol para aspergilosis.
Inhiben la 14-α demetilasa (inhibe CYP450), bloquean la síntesis de ergosterol.
Mecanismo
Fungistático. Resitencia debido a disminunción en la concentración intracelular.
Efectos
Teratógenos, Náusea, vómito, cefalea y exantemas cutáneos.
adversos
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