CPJE HIV Brand/Generic/Class correctly answered 2023

CPJE HIV Brand/Generic/Class correctly answered 2023NRTI Class BBW Lactic Acidosis and severe hepatomegaly with steatosis, esp. stavudine, didanosine, and zidovudine Ziagen Abacavir (ABC) - NRTI Epzicom Abacavir, lamivudine - NRTI x2 Trizivir Abacavir, lamivudine, zidovudine - NRTI x3 Videx, Videx EC Didanosine (ddI) - NRTI Emtriva Emtricitabine (FTC) - NRTI Truvada Emtricitabine, tenofovir - NRTI x2 Atripla Emtricitabine, efavirinz, tenofovir - NRTI, NNRTI, NRTI Complera Emtricitabine, tenofovir, rilpivirine - NRTI x2, NNRTI Stribild Emtricitabine, tenofovir, elvitegravir, cobicistat - NRTI x2, Integrase Inhibitor x2 Epivir Lamivudine (3TC) - NRTI Combivir Lamivudine, zidovudine - NRTI x2 Zerit Stavudine (d4T) - NRTI Viread Tenofovir (TDF) - NRTI Retrovir Zidovudine (ZDV or AZT) - NRTI NRTI Drug interactions Ribivirin increases all NRTI (increase lactic acidosis); Avoid didanosine/stavudine combo (both pancreatitis); Avoid didanosine/tenofovir combo (resistance, increased ddI conc); Avoid emtricitabine/lamivudine combo (both cytosine analogs - no benefit); Avoid zidovudine/stavudine combo (both thymidine analogs - antagonistic effect) NNRTI Class Side effects Rash (SJS/TEN); Hepatotoxicity Rescriptor Delavirdine (DRV) - NNRTI Sustiva Efavirenz (EFV) - NNRTI Intelence Etravirine (ETR) - NNRTI Viramune, Viramune XR Nevirapine (NVP) - NNRTI Edurant Rilpivirine (RPV) - NNRTI NNRTI Drug interactions All NNRTI's cleared non-renally and hepatically metabolized via CYP 450 system, MANY cyp drug interactions Protease Inhibitor Class Side Effects Hyperglycemia/insulin resistance, diabetes, lipoatrophy, fat maldistribution, hypelipidemia, hepatitis/hepatic decompensation (highest with tipranivir), immune reconstitution syndrome Reyataz Atazanavir (ATV) - PI Prezista Darunavir (DRV) - PI Lexiva Fosamprenavir (FPV) - PI