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Samenvatting Metabolisme - module 7
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GESLAAGD EERSTE ZIT! - gedetailleerde samenvatting van module 7.
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Module 7 : Lipidentransport en atheroscleroseCholesterol is zeer slecht oplosbaar in water, maar goed oplosbaar in serum (plasma)
7.1 Lipoproteïnen verpakken onoplosbare cholesterolesters en triglyceriden
• Cholesterol: wordt verpakt in halve lipiden-enkellaag
o Kern: zeer slecht oplosbare cholesterolesters (=> apolair)
o Halve membraan: bevat apoproteinen, vrije cholesterol en fosfolipiden (=> polair)
-> interactie met plasma
• Lipoproteïnen: bevatten cholesterol
o Chylomicron
o HDL : hoge densiteit -> meer eiwitpercentage -> “goede” cholesterol
o LDL : “slechte” cholesterol
• Apoproteinen: adresseren lipoproteinen naar bestemming + ondersteunen een taak dmv
transport of katalyse
7.2 Lipidentransport
1) Productie chylomicronen 7
5
o In dunne darm
o Post-prandiale fase (verterings/opname fase) 5
eliminatie van
cholesterol
o Lymfe -> cava superior -> hart -> vetweefsel CETP de novo
6
lever
aangemaakt 4
8 cholesterol voedingscholesterol
9
2) Lipase vormt triglyceriden/remnants 3
o INDIEN DIERLIJK VOEDSEL
2
o Bevat cholesterol
2
o In vetweefsel resorptie door
vetweefsel
o Transport naar lever 1 dunne darm
lipolyse
3) Productie VLDL chylomicronen
remnants
o INDIEN PLANTAARDIG VOEDSEL VLDL
excretie van
o De novo cholesterol synthese LDL
10 cholesterol
HDL als galzouten
o In lever
4) VLDL wordt omgezet in LDL
o In vetweefsel
o LDL vervoert cholesterol doorheen heel lichaam
5) Contact tussen HDL en LDL
o HDL gaat naar lever -> excretie cholesterol via galzouten
o LDL gaat naar bloedvaten -> atherosclerose!!!
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