Summary
Samenvatting leerpad B pneumo 2
- Course
- Institution
leerpad B - verdiepend 4
[Show more]
Seller
Followmarthevanhulle
Reviews received
Content preview
LEERPAD B: PATHOLOGIE – PNEUMO 2MUCOVISCIDOSE (CYSTISCHE FIBROSE, TAAISLIJMZIEKTE)
OORZAAK
Gezond gen codeert voor transmembraaneiwit dat als regelbaar chloorkanaal optreedt:
normaal volgen watermoleculen chloorionen via osmose
Gevolgen:
– Geen watersecretie
– Indikking mucus
* CFTR-gen = cystic fibrosis transmembrane regulator
ADEMHALINGSSTELSEL
Gecompliceerde mucociliaire lift
Hoesten en opgeven taaie slijmen
Recidiverende luchtweginfecties
Clubbing
Progressieve longdestructie
Overlijden
SPIJSVERTERINGSSTELSEL
Pancreas:
– Exocriene insufficiëntie door obstructie ductus pancreaticus
§ Steatorree door tekort lipasen in spijsverteringskanaal
§ Vetoplosbare vitaminen-deficiëntie (A, D, E, K)
§ Malabsorbtie en vermagering
§ Meconium ileus
– Endocriene insufficiëntie door destructie eilandjes van Langerhans
§ Diabetes type II
Lever:
– Levercirrose
– Portale hypertensie
– Slokdarmvarices → hematemesis
1
, DIAGNOSE
Zweettest
– Cave: normaal CFTR-gen zorgt ervoor dat merocriene cellen chloor reabsorberen →
gemuteerd CFTR-gen leidt ertoe dat er hoge concentraties chloor opgestapeld
worden in ducti
– Verhoogde concentratie chloor in zweet is dus indicatief voor mucoviscidose
– Medicijn pilocarpine in de huid leidt lokaal tot zweten → zweettest
Genetische test
– Ter bevestiging zweettest
– 500 mutaties CFTR-gen gekend
– Dorothine Andersen (1901-1963) → ‘Andersen syndroom’ John-Hopkins University in
Baltimore
BEHANDELING
Ademhalingskinesitherapie
Behandeling infecties
Toediening pancreasenzymen
Toediening vitaminesupplementen
Longtransplantatie
LONGEMBOLIE
OORZAAK
Klonter van bloed, weefsel of gas in de arteria pulmonalis (zie slide 28 les 1)
– Door diepe veneuze trombose (triade van Virchow: bloeddebiet↓, stollingsgraad↑,
vaattrauma)
– Door rechter voorkamerfibrillatie
MASSIEF LONGEMBOOL OF ZADELEMBOOL
Cardiovasculaire collaps
KLASSIEK MIDDELGROOT EMBOOL
Longinfarct
2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller marthevanhulle. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.77. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67474 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now