Metabolic Spring Test 2| 204 questions| with complete solutions
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Course
Metabolic
Institution
Metabolic
All humans suffer from hypoascorbemia? (T/F) correct answer: True
Which enzymes require folate as a co-substrate? correct answer: Methionine synthetase, MTFR, SHMT
Which mineral is an essential factor in the action of glutathione peroxidase (GPX) in the reduction of organic peroxides and hy...
metabolic spring test 2| 204 questions| with complete solutions
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Metabolic Spring Test 2| 204 questions| with
complete solutions
All humans suffer from hypoascorbemia? (T/F) correct answer:
True
Which enzymes require folate as a co-substrate? correct answer:
Methionine synthetase, MTFR, SHMT
Which mineral is an essential factor in the action of glutathione
peroxidase (GPX) in the reduction of organic peroxides and
hydrogen peroxide? correct answer: Selenium
What is a genetic disorder that ultimately results in the excessive
accumulation of iron in certain tissues. This disorder affects all
iron-requiring enzyme reactions as well correct answer:
Hemochromatosis
Which mineral participates in all aspects of energy metabolism
including glycolysis, beta-oxidation and the TCA cycle? correct
answer: Magnesium
What enzymes require thiamine, in the form of TPP for full
activity? correct answer: BCKD complex, PDH complex, and
alpha KG complex
A riboflavin deficiency would affect the ETC (T/F) correct
answer: True
,What are the required cofactors in the ETC? correct answer:
Copper, iron, and zinc
Riboflavin co-enzymes remain bound to their enzymes during
the oxidation-reduction reactions they participate in. The
complexes are called correct answer: Flavoproteins
Why does thiamin utilization increase in cancer patients? correct
answer: Thiamin is necessary in the Pentose Phosphate
Pathway, which is up-regulated in cancer
Thiamine is important to fatty acid synthesis due to its
requirement as what co-enzyme for the hexose monophosphate
shunt (pentose phosphate pathway)? correct answer:
transketolase
Phosphate induces a conformational change in the pyruvate
kinase enzyme (T/F) correct answer: False-- potassium does
Which mineral acts as a chelating agent for ATP (i.e. binds it)?
correct answer: Magnesium
Which vitamins are required for the fatty acid oxidation (beta-
oxidation) pathway? correct answer: Pantothenic acid,
riboflavin, and niacin
Mild niacin deficiency can cause an intolerance to cold (T/F)
correct answer: True
The ETC requires NADPH (T/F) correct answer: False
, What is the purpose of antioxidant production? correct answer:
Balancing free radicals
In glycolysis what enzyme serves as a bridge between the
enzyme and ATP? correct answer: Magnesium
In the paper you read on Scholar, what were the findings related
to Vitamin D and obesity? correct answer: Supplementation
with Vitamin D lead to increased fat mass loss in subjects
What does fatty acid entry into the cell require? correct answer:
Pantothenic acid
What does carnitine synthesis require? correct answer: vitamins
C, B6, niacin, and iron
What is formed during beta-oxidation of fatty acids? correct
answer: Acteyl-CoA, FADH2, NADH
What vitamin transcriptionally regulates the genes involved in
beta-oxidation? correct answer: Vitamin D
One sign of B6 deficiency is Pellagra like symptoms (T/F)
correct answer: True
Can folate supplementation prevent NTD in shmt1KO? correct
answer: Folate only (not chlorine)
What might be the consequence of an SHMT2 KO? correct
answer: Reduced one-carbon metabolism-renal tube defects and
anemia
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