Class notes
Psychopathology and Psychopharmacology Radboud Lecture 3
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Slides with hand-written notes about the third Psychopathology and Psychopharmacology lecture. With important information for exam and resit.
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Test Bank Stahl’s Essential Psychopharmacology 5th Edition All Chapters Fully Covered A+ Guide Completed ISBN:9781108971638 Newest Version Stahl’s Essential Psychopharmacology 5th Edition Test Ban...
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Stahl’s Essential Psychopharmacology 5th Edition Test Bank
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Test Bank Complete_ Stahl's Essential Psychopharmacology Neuroscientific Basis and Practical Applications 5th Edition, (2021) Stephen M. Stahl (Author) All Chapters 1-13
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Psychopharmacology& Psychopathology
SOW-PSB3BC16E
Topic 1: Principles of psychopharmacology
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Hanneke den Ouden
, Effects of a drug or neurotransmitter depend on the receptor…
§ Affinity
§ Location (where in the brain)
§ Where on the agonist/antagonist spectrum?
§ Type of receptor (G-protein coupled, ion channel…)
Let’s go check
me out!
5
, 2nd messenger linked subtypes of dopamine receptors
Receptor subtype
adenylate cyclase
Brain region
synthesizes
2nd messenger effect
cAMP D2 -
like
receptors
Agonists (PA = partial)
Antagonists AKA
↓ ☐1 -
5
OR
☐1 like
-
receptor
6 174 and D 5 don't target the cortex .
With different receptor sub types you can
target different parts of the brain
-
Almost all Of the drugs work more on D2
.
type receptors
-
D1 types have low affinity for
-
dopamine
when there's too much dopamine the
, ☐z inhibition is over corned and goes
to D1 excitation
, D2
1) 1 V5 D2 receptors receptors localized presinepti Cally
-
: and posts inaptically .
number of
high affinity for a bro
-
same neurotransmitter , different effects .
drugs Cano
time and
morphine
dopamine
, mocrip
] that act
-
8
as
agonists .
-
the ability to block the D2
receptor is not uniform
2nd messenger-linked and ligand gated subtypes of Serotonin receptors inhibitory
-
dopamine in hi bite it
-
.
antipsychotic action and
-
extrapyramidal side effects
of classical
Receptor subtype a function of
neuroleptic are
dopamine D2 like
receptor brocade
-
Location
.
2nd messenger effect
Agonists (PA = partial)
Antagonists
D1
-
Most abundant in the
brain .
-
the role in psychiatric
disorders is unclear .
evidence
suggests
-
that
they affect behaviour
indirectly
regulatorythrough
their
tire
effects in D-2
receptors .
-
their
stimulation has a
synergistic effect on the
D2
receptor motor
to
dopamine response
development of
-
D1 and D2
agonists such as
cpermllt) for pergo ride
the
Parkinson's treatment Of
.
excitatory
-
dopamine
-
activates it
8 .
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