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Samenvatting Farmacotherapie deel diagnostische: ongewenste effecten geneesmiddelen obv van artikel BCFI
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Farmacotherapie deel diagnostische: ongewenste effecten geneesmiddelen obv van artikel BCF tabelvorm
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Ongewenste effecten Risicofactoren GeneesmiddelenQT-verlenging torsades de Combinatie van risicofactoren NIET diltiazem, amiodarone, verapamil
pointes 2 QT-verlengend GM - Ranolazine
(=ventrikeltachycardie)!! QT-verlengend + GM die zijn - Anti-aritmetica (cibenzoline,
afbraak inhibeert dispyramide, flecaïnide, sotalol,
QT-verlengend + vernakalant)
bradycardiserend GM - Domperidone
QT-verlengend + K-verliezende - Ondansetron (5HT antago)
diuretica - Terlipressine
>65j - Methadone
Vrouwelijk - Hydroxychloroquine
Hartlijden - Antipsychotica (droperidol,
Elektrolytenstoornissen levomepromazine, pimozide,
Congenitaal lang QT-syndroom sertindol, sulpiride, haloperidol)
- Citalopram en escitalopram
- Guanfacine, pitolisant
- Donepezil
- Erythromycin, azithryomycine,
clarithromycine, roxithromycine
- Bedaquiline
- Fluconazole
- Arthemeter + lumefantrine,
artenimol + piperaquine, kinine
- Pentamidine
- Hydroxyzine
- Oxaliplatine
- Inotuzumab ozogamicine
- Biologicals: alles op – inib
- Anagrelide, arseentrioxide,
Panobinostat
- propofol
Anticholinerg Contra-indicaties Anticholinergica
centraal: duizeligheid, - gesloten hoek glaucoom - butylhyoscinebromide
cognitieve achteruigang, - refluxoesofagitis (abdominale krampen)
agitatie - prostaathypertrofie - anticholinergica bij
perifeer: monddroogte, - intestinale atonie blaasfunctiestoornissen, astma,
droge ogen, verminderde - parlytische ileus COPD, parkinson
zweet, nausea, obstipatie, - colitis ulcerosa - mydriatica
mydriase, urineretentie, - myastenia gravis - cycloplegica
tachycardie, ritmestoornis Risico - atropine
- hyperthermie antidepressiva
- pylorusstenose - amitriptyline
- tachycardie - paroxetine
- hypertensie H-antihistaminica
- AMI - difenhydramine, meclozine,
voorzichtig bij kinderen en ouderen: dimenhydrinaat, hydroxyzine,
verlagen dosis antipsychotica
- fenothiazines, clozapine,
sedatie indien combinatie met alcohol haloperidol, olanzapine, pimozid
of sederende middelen quetiapine
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