In this file you will find a Rapid Revision Summary for the Biochemistry part of Krok 1. A part of the summary is based on most frequent asked questions as well as ministery questions.
Dihydrofolate
7) Reductase =) helps in DNA Synthesis c Mononudeoti
Synthes
Biliary Tre Requires Bar Follic Acid
->
as cofacto
inhibited Methotrexate
->
by Dag
Bite is secreted ↳inhibits DNASyn. &Bg
liver
by Inhibits
Anti-Cancer
MAF- THE
drug
=>
Bile is stad & 0) Amatidine present =
in Mushroom, Causes
Mushroompoisining
↑
i n Gall
concentzate
(Death (up) Inhibits RNA
polymerase II (inhibits transcription)
->
Bladder
9)Porphyria/Vampire
disease HEME
-
Synthesis
concentzate
stage of De maisicatesphinter te
-
open dag
->
takes place in Mitochondria &
Cytoplasm of liver
Bile ing of oddi
Duodenum URopophyzinogen co-II
Synthase enzyme deficien
->
on
A Maja papillae 4 U-p-co-
->
Pink wine
<opening)
Longitudinal
Folds present 10) Duchenne Muscular Dystrophy - Wheel chair
disease
Bile ductobstruction -
Bile problem =
NO FAT ↳ Absence of Dysteophin & Creatine Kinase 4tmm
↓
Beckers Muscular
O FAT ABSORPTION
N
↓
11) Dystrophy -
Bad
Dystrophin
Becomes 1 Fat Soluble Vitamin Messengel
10 hormones =
Essential (cannot absorb) ba that dus wat Pa
(musttake i it
A, D, E, K 12) Secondary Messengen [Amp] (transpat harmones from
(watchmen) 1-CAMP-Lipase,
-
etc. membrane to nucleur m
2) Galactosemia individual not able to metabolize Galactose 2 cGMD-NitricOxide & Azterial Natudic Fadez
-
-
(AN
A
Genetic Disorder-Galactose I phosphate Uridy Transferase 3-1P3 -
Iositol Tiphosphok (uses Cat
↳ (deficiency) ↳
Typical Galactosemia ee
Angioten Is
cause used
by e.g. Epinehren
O
Classical Galactosemia 7 -
Di
acys glycand in vasoconstride
ves
-> Oil Drop Catart is seen
3) Eructosemia Aldolase
Benzyme deficiency [FAB] B3) DNA Enzymes
=
n
mainly liven, kidney & intestine 1 Helicase
unwinding the 2 strands
->
in -
->
4)
Glycogenesis ->
Synthesis of Glycogen (Branched 2-Topoisomerase -
Super Colling
Basal alle
polysacharide a
storage form in animals)
3-ligase -
Helps in
joining Con dissue
genesis -
farming ↓ ↓
lysis-breakdown
->
Enzyme;Glysogen Synthese 4 - Endonuclease - DNA Repair
Regeneration
Insulin stimulates ↳ Endonuclease
->
glycogenesis, activates deficiency cause Xenoderma
pigmentosa
↳ Glucose
↓ By UV-midiation.
5) Glycogenolysis Breakdown of Glycogen (4) Phospholipase A2-> helps in Azachinoidic Acid
Synthesis
-
From phospholipids through Cox &
goes
->
Enzyme; Glycogen phosphaylase [Gp] 15) Antioxidants Lox
pathway
->
Glucagon stimulates Glycogendysis Vitamins - VitA
AsCE
MC ARDLES Disease
Deficiency
=
of GP in Muscles vit C
↳
types glucogen stage
disease vitE (mostpotent antioxidant)
HER'S Disease
Deficiency
=
of Gp in liver (type 6)
Proteins -
1 Transferrin (transport
iron fel
C42+
6) Gluconeogenesis -
Formation of Glucose from other than Carbo- 2 Guloplasmin staes & transpats
copper from li
hydrate of body
into bloodstream to part
->
enzyme;
Glucose 6 phosphatase (mainly present ↳ deficiency-> Wilson Disease
in liver go-g5y)
VON GIRKE
Disease 3 Albumin-> most Abudant protein Blood
Type Iglucogen stage disease sy.
kidney in
-
->
Absence of Glucose 6 phosphatase ↳ fluid from leaking out of bloodves
prevent
&transpats, hamones, vit & enzymes
4 Glutathione detoxification->
, Enzymes 1
Super Oxide Dismudase Q incase of Wound, Oxidative
Recaboxylation -
Scoenzymes used
we will use H202 ↓
Liberate CO2
2
Hydrogen penoxidase <
(Thiamine
Tpp pyrophosphate) B,
Catalase
Hase, H20+02 >COA
(in skin)
①
3 active fam of Bs
↓ 00
fams bubbles
4 Glutadhione Denoxidase =
>lipoamide (lipoic Acid) -
inhibited
by
of bact.
anemy Sodium Azsenat
3 Glutathione Reductase >NAD Be
+
an >FAD
septic
B2
↳ Examples; alls-I
↓use
16) Blocked
ATP
=>Resting Membrane Potential will disappear Pyzuvate
Dehydrogenese complex (PDC)
Branched chain Kedo
17)
Jaundice Dehydrogenase(BckD
of Alpha keto Glutamate
Hemolytic jaundice -
Breakdown RBC
Dehydrogenase (A-kGDH
Aka prchepadic jaundice
I ·Unconjugated/indirect / Non soluble
Bildwin Enzymes &
Prosthetic Go
t
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