Summary
Samenvatting module 2.4: afweer
- Course
- Institution
samenvatting module 2.4: afweer
[Show more]
Seller
Follow
rubenvanvaerenbergh
Reviews received
Content preview
Module 2.4: afweer:Wat is afweer:
• reactie tegen lichaamsvreemde bestanddelen
• doel: eliminatie / autonome, ‘passieve’ bescherming
• afweersysteem
= immuunsysteem
= immunologisch systeem
➔witte bloedcellen + lymfesysteem = leukocyten = lymfatisch systeem
Afweersysteem vertoont dichotomie:
Bestanddelen van afweersysteem:
• fagocyten
• NK cellen
• B-, T-lymfocyten
• Antilichamen
• Epitheelbarriere
Hoe werkt de afweer:
28
, Eerste verdedigingslinie:
Huid en slijmvliezen:
• Mechanische bescherming
▪ Meerdere lagen epitheel
▪ Acellulaire hoornlaag huid
▪ ‘tight junctions’ tussen de epitheelcellen
• Talg- en zweetsecretie huid
• Trilharen en slijmlaag op slijmvliezen
• Zuurproductie
Stoffen met antimicrobiele eigenschappen
Collectinen en interferonen
Cellulaire elementen van de niet-specifieke afweer:
• Mast cellen
• Macrofagen
• Granulocyten
• NK-cellen
• ILC
Mast cellen:
• Vooral aanwezig in weefsel
▪ In buurt bloedbaan
▪ Submucosaal van weefsel in contact met buitenwereld
• Uit myeloide precursor?
• 2 types:
▪ Bindweefsel type
▪ Mucosaal type
• Activatie door
▪ Directe aspecifieke trigger
▪ Specifieke stimulus
• Vrijzetting mediatoren
Fagocytose:
• Door macrofagen en granulocyten
• Opsonizatie bevordert fagocytose
• Endocytose en intracellulaire vertering
Patroonherkenning door cellen van aangeboren immuunsysteem:
• Groepen van moleculaire patronen op micro-organismen worden door bepaalde receptoren
herkend
• 2 klassen van receptoren:
▪ PAMP (pathogen-associated molecular patterns)
▪ Evolutionair geconserveerde structuren op micro-organismen
▪ Ontbreken op humane lichaamscellen
▪ Binden TLR, Nod-eiwitten, C-type-lectinen
▪ Bv: LPS, endotoxine, PG, viraal DNA
- DAMP (danger-associated molecular pattern
29
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller rubenvanvaerenbergh. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $4.82. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
64450 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 15 years now