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Samenvatting module 2.6 beweging
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samenvatting module 2.6: beweging
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klierstelsel:• klierorganen die stiffen uitscheiden
• productie
- (exocrien)
- Endocrine
Oxytocine:
Diabetes mellitus symptomen:
Selye’s concept van stress:
• In verschillende experimenten stelde Selye proefdieren bloot aan schadelijke stoffen en vond
dat ze allemaal reageerden met hetzelfde syndroom van veranderingen, of stress triade
• Stress triade:
- Groeien bijnieren
- Krimpen lymfatische organen
- Bloedingen via gastro-intestinale ulcera
Stress= niet-specifiek stereotiep responspatroon dat tot ontwikkeling komt in reactie op belasting van
welke aard ook, als reactie op schadelijke prikkels, lichaam bereidt zich voor op actie. In 3 fases:
alarmfase, weerstandsfase, uitputtingsfase
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, Module 2.6: beweging, inspanning en immobiliteit:
Hoe is botweefsel opgebouwd:
• Botmatrix of osteoïd
• 3 type botcellen
- Osteoblast
- Osteocyt
- Osteoclast
Wat is de botmatrix:
• Collageen
• Proteoglycanen : chondroïtine en keratine sulfaat
• Glycoproteinen
- Osteonectine en osteocalcine
- BMP= bone morphometric proteins
• Mineralen
- Ca, P
- Omgezet tot hydroxyl-apatiet
• H2O
Hoe wordt de integriteit van botweefsel gerealiseerd:
Remodeling bot
• Door bot-remodeling unit
• 3 fazen
Wat is OPG/RANKL/RANK systeem:
• OPG = osteoprotegerin
• RANKL= receptor activator of nuclear factor kbèta ligand
Osteoporose:
• Idiopathische vs secundaire osteoporose
• Normale miniralizatie maar afgenomen dichtheid
- Normal bone > 833mg/cm2
- Osteopenia 833 tot 648 mg/cm2
- Osteoporse <648 mg/cm2
• Veralgemeend of regional (axial skelet)
• Risico op fracturen
• Op leeftijd van 90 jaar hebben 17% mannen en 32% vrouwen een heupfractuur
Hoe s kraakbeen opgebouwd:
• Chondrocyten en matrix
- Collageen
- Proteoglycanen
- H2O
• Geen bloed-, lymfevaten en zenuwen
• O2 & voedingvia diffusie
• 3 types kraakbeen
- articulair, hyalien
- Fibrocartilaginair
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