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Practica samenvatting - MLT 04
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Volledige samenvatting over alle practicalessen in MLt04 met afbeeldingen.
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PracticaHematopoëse
= aanmaak bloedcellen (WBC/RBC) en plaatjes (T)
▪ Volwassene: beenmerg van axiale, skeletale of lange beenderen
▪ Foetus:
o 2,5 – 5 weken: dooierzak/ventraal endotheel dorsale aorta → enkel RBC
o 6 weken: lever → volledige hematopoëse
o 12 weken: beenmerg → volledige hematopoëse
▪ Bij noodzaak: milt/lever = extramedullair (op latere leeftijd)
▪ Menselijk lichaam:
o 3,8-5,8 . 1012/L RBC
o 4-10 . 109/L WBC → Verhouding RBC/WBC = 103
9
o 1,5-4,5 . 10 /L T
o Verhouding witte bloedcellen:
▪ Neutrofielen 30 – 70 %
▪ Eosinofielen 0 – 6 %
▪ Basofielen 0–2%
▪ Monocyten 0 – 10 %
▪ Lymfocyten 20 – 45 %
▪ Uitstrijkjes/kleuringen
o May Grunwals Giesma (PB+BM) → algemene beoordeling en differentiatie
o Ijzer/Berlijns blauw (BM) → vermoeden dysplasie, functioneel ijzertekort
o Myeloperoxidase kleuring (PB+BM) → classificatie acute leukemie want
kleurt enkel myeloïde cellen aan
1 De rode reeks
Erythropoëse inclusief uitrijkingsstatia
Proerythroblast = normoblast
(vaak met 2 lobjes) N/C↑
“Mickey Mouse”
Basofiele erythroblast
↓
Polychromatische erythroblast
↓
Orthochromatische erythroblast
↓
Reticulocyt → polychromasie
Rode bloedcel N/C↓
Normaal: alles voor rode streep: beenmerg, alles erna: perifeer bloed
Alle gekernde voorkopers = normoblasten (alles boven rode streep)
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