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Physiology of Ageing - week 2 - 2023 - Physical changes to the structure of the surface anatomy and structural integrity of the skin - FdA/BA Aesthetic Practitioner Year 1$17.55
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Physiology of Ageing - week 2 - 2023 - Physical changes to the structure of the surface anatomy and structural integrity of the skin - FdA/BA Aesthetic Practitioner Year 1
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Course
Physiology of Ageing (870)
Institution
University College Birmingham
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Aesthetic practitioner - physiology of ageing - week 2 - 2023 - physical changes to the structure of the surface anatomy, structural integrity of the skin.
Subjects
physiology of ageing
anatomy
skin
aesthetic practitioner
ageing
exam preparation
assignment study
comprehensive notes
lecture notes
Written for
University College Birmingham
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Physiology of Ageing (870)
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Content preview
Physiology of ageing – Physical changes to the
structure of the surface anatomy, structural integrity of
the skin.
Table of Contents
Physiology of ageing – Physical changes to the structure of the surface anatomy, structural integrity of the
skin. ...............................................................................................................................................................1
Quick Review: ................................................................................................................................................... 3
Extracellular Matrix (ECM) ............................................................................................................................... 4
Papillary layer .................................................................................................................................................. 5
Reticular Layer ................................................................................................................................................. 6
Dermal Epidermal Junction (DEJ) ..................................................................................................................... 7
Cell Junctions .................................................................................................................................................... 8
The ECM extracellular matrix – biomolecules ................................................................................................ 11
Biomolecules .................................................................................................................................................. 12
Fibroblast ....................................................................................................................................................... 12
Elastin ............................................................................................................................................................ 13
Collagen ......................................................................................................................................................... 14
Collagen: The triple Helix ............................................................................................................................... 15
Epidermal Growth Factors ............................................................................................................................. 15
Proteoglycans ................................................................................................................................................ 16
Matrix Metalloproteinase (MMP’S) ............................................................................................................... 16
Contributing factors to Free Radicals Formation ........................................................................................... 19
The Science of Glycation and Advanced Glycation End Products (A.G. Es) .................................................... 20
Preventing Glycation and AGE Formation...................................................................................................... 22
The Rubin Photo Ageing Analysis Classification Scale .................................................................................... 23
The Glogau Phot-damage Classification Scale ............................................................................................... 23
Dynamic Rhytids............................................................................................................................................. 23
Static Rhytids ................................................................................................................................................. 24
Mimetic Wrinkles and Folds ........................................................................................................................... 26
, Smoking and Wrinkles.................................................................................................................................... 27
Age related changes ...................................................................................................................................... 30
REFERECNE ..................................................................................................................................................... 34
2
,Quick Review:
EXTRINSIC/INTRINSIC FACTORS starting from the one who has the most
impact on skin ageing:
According to Aesthetic Journal, one of the key mechanisms
behind inflammation-induced ageing (both intrinsic and
extrinsic) is the generation of:
Reactive Oxidative Species
Smoking and pollution are known to be caused by ROS- both of
which cause inflammation and are regarded as central tenets of
skin ageing (McCarthy, F Dr, The science behind inflammation
and ageing (Aesthetics Journal, Volume 5, issue 10, September
2019).
3
, Extracellular Matrix (ECM)
• An extracellular matrix (ECM) is a prerequisite for multicellular life.
It is adapted to tissues and constantly undergoes changes to
preserve microenvironmental homeostasis. The ECM acts as a
structural scaffold that establishes tissue architecture and
provides tensile strength (Nystrom & Bruckner-Tuderman, 2019)
4
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