A comprehensive, yet concise summary of the Thyroid topic in Medicine/ Surgery, presented in a colourful and digestible format. Includes all relevant information on the topic summarised, collated from multiple resources including lectures, textbooks, and guidelines. All my notes/ summaries use a co...
Endocrinology
Thyroid from Anterior
HPT AXIS
Produces is and Ty, stimulated Pituitary.
by
·
TSH
Ts is
biologically active.
Synthesised from Thyroglobulin precursor.
Ty abundantly produced, and is decodinised Ts.
·
is more to
80% of is comes from Ty, 20% is
synthesised by thyroid.
There is more free is than Ty.
Protein.
T/4 bind to proteins when in blood.
Thyroxine Binding
·
e.g.
Hypo:Free TSH (t feedback) Hyper:Free TSH (-feedback)
Free T3 Free T3
Free T4 Free T4
Hyperthyroidism
with mild
normocytic anaemia and
·
GOITRE
·
Thionamide Drugs:
Carbimazole/Progylthiouracil (+B blocker to reduce symptoms).
·
Used to enter remission or
prepare for other treatment.
lead to monitor infection risk.
·
can neutropenia so
·Radioiodine
Therapy:radioactive iodine pill, iodine taken up by thyroid and radiation
destroys it.
·
Used as first-line, or after Thionamide if disease doesn'tresolve.
·
become
most hypo. post-treatment, can affectfertility, must self-isolate after.
Thyroidectomy:risk ofhoarse voice due to Recurrent for life.
·
Laryngealn. damage, needs L.
Thyroxine
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