A comprehensive, yet concise summary of the Pituitary topic in Medicine/ Surgery, presented in a colourful and digestible format. Includes all relevant information on the topic summarised, collated from multiple resources including lectures, textbooks, and guidelines. All my notes/ summaries use a ...
CORTISOL SECRETION
GHEATHWAY
A. Hormones
·ACTH:stimulated by CRH.
·
Promotes Cortisol Secretion from adrenals.
low
levels in
Very sleep, high
·
in
morning.
ACTH Adrenal
hyperplasia,
· =
ACTH Adrenal GH PULSATILE
SECRETION
Atrophy.
=
o
TSH: stimulated by TRH.
Promotes Ts/Tyrelease from Thyroid.
·
·
Negative feedback from Ts/Fr.
·FSH/CH:stimulated by GnRH.
Promote sex hormone release from gonads, inhibited
by
·
to induce other
secondary effects. Prolactin:
Dopamine.
·
going on
·GH: stimulated by GHRH, inhibited by Somatostatin. ·Induces lactation,
Suppresses GnRH.
Regulates many growth/metabolic functions. during
abundant
· ·
more
·
Released in zulsatile pattern higher in sleep.
-
pregnancy/breastfeeding.
·
Liver produces IGF-1 in response, which modulates GHeffects.
IGF-1levels can be used to screen for GH oversecretion.
·
stimulated by hypoglycaemia, sleep, exercise.
Suppressed by hyperglycaemia.
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