Proces begint: visueel pigment rhodopsine
Fototransductie geactiveerd -> inval licht
Activeert G-proteïne (transducine) -> enzyme
fosfodiësterase activeert -> breekt cyclisch
guanosine-monofosfaat (cGMP) ->
cytoplasmaconcentratie second messenger dalen =
cGMP-gated ion channels geopend en
depolariserende Na-influx.
Donker: concertatie cGMP afnemen -> Na-kanalen
sluiten en instroom Na afneemt = cel
hyperpolariseren + calciumkanalen sluiten
4
Bipolaire en Fotoreceptorcellen retina maken synaps
ganglioncellen van bipolaire cellen -> synaps met ganglioncellen -
de retina > signl hersenen
Fotoreceptorcellen: convergeren op bipolaire
cellen prikkels uit bepl respectief veld
Naast verticale transmissie wordt signl
overdracht ook lateraal beïnvloed en
gemoduleerd door horizontale en amacriene
cellen retina.
5
Signl bipolaire cellen -> ganglioncellen, waar
graduele receptorpotentialen omgezet in
Gradueel
actiepotenialen
Glutamaat On-center-bipolaire cellen zullen on-center-
Gradueel ganglionaire cellen depolariseren en tot
actiepotentiaal aanzetten.
Off-center-bipolaire cellen hyperpolariseren
AP off-center-ganglionaire cellen.
3
2
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