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samenvatting h3 neurale signalen
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samenvatting hoofdstuk 3 neurale signalen slides les 3 aangevuld met boek + les notities
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margovandenplas
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21/05/2023Hs. 3
Neurale signalen
1
Chemical driving force Electrical driving force
Exciteerbare cellen elektrische prikkels
kunnen ontvangen en geleiden
Elektrische activiteit stromen geladen
deeltjes door/ langs celmembraan
2
elektrofysiologie Hydrofiele stof goed oplost in water
Hydrofobe stof niet goed oplost in water
Celmembraan Scheid: intracellulaire
cytoplasma en extracellulaire weefselvocht
Elektrisch potentiaalverschil concentratie
verschil geladen deeltjes buiten en in
celmembraan
Rustmembraam potentiaal -70mV
3
1
, 21/05/2023
rustmembraanpotentiaal
Chemische drijfkracht concertratiegradient:
Meting van membraanpotentialen
hoge naar lage concentratie
micro-electrode (punt <1µm)
Elektrische drijfkracht potentiaalverschil:
aantrekkingskracht positieve en negatieve ladingen
Membranen door lipiden samenstelling niet
doorlaatbaar voor ionen
In kanalen toestand ontstaat geen beweging
=
mogelijk chemische kracht tegengesteld aan
Geen
potentiaalverschil
elektrische kracht
Evenwichtspotentiaal is elektrische spanning nodig
chemische drijfkracht tegen te werken
4
rustmembraanpotentiaal
5
Exiteerbare cel reageert op stimuli
doorlaatbaarheid ionen selectief aan te
passen wijzigt elektrische polariteit van
membraam potentiaalverschil groter of
kleiner.
Depolarisatie potentiaalverschil kleiner
(bv.: influx Na)
Hyperpolarisatie potentiaalverschil
toeneemt
3
2
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