provide revision and bollet point for immunology basics, starting from understanding immune system and diffrent cells and their function , the receptors involved and the mediators that are expressed to how the body deal with disease, inflammation , autoimmunity , immunophaocology, immunisation vacc...
Immune system: a diffuse, complex network of interacting cells, cell
products and cell forming tissues that protects the body from
pathogens & other foregin substances, destroys infected Umalignant cells & removes cellular debris.
include
tasks: 1. defense response 2. removal of dead tissues/cells 3.repair Shealing 4. immunological memory
5. Communication between man lymph - 2 biological fluid for immune cells.
a
Immunity: the balanced state of multicellular organisms having adequate biological defenses to fight infection, disease/unwanted
biological invasion, while having adequate tolerance to avoid allergy & autoimmune diseases.
passive defense: ph, skin, small peptides, soluble molecules (enzymes)
Immune system >
innate
PRRS
active defense - recognition receptor, the phagocytes, cytokines,
pattern
a immune response: PAMP: molecules associate with go of pathogens
-As first contact with immuneresponse. refer a small molecular motifs conserved within a class of microbes.
Forfiretia ovodepositesor
-leave to
recognise the Ag blouse I
recognition for fungi o, bacteria 8, viruses
LDAMPself en
immune ate
②secondary immune response: Summery
- end, Erd ... the person is exposed to the same way
- immunological memory stablished.
Immunopharmacology: part of pharmacology that deals with drugs acting
on the immune system, pharmacological actions of
substances derived from the immune system.
Biologics: genetically engineered proteins derived
- from human genes, designed to
inhibit specific component of the immune system.
Immunotherapies: therapies that enlist & strengthen the power of
patient's immune system.
kines: movement, activity 2
be
, NADPH -> oxidase detect cause, the
phagocyte to be unable to make reactive O2 radical required for bacterial killing
so-abacteria may thrive from phagocyte.
NBT: a test to assesses phagocytic functions. (ablue score,better the cell
producing reactive O2 species)
Hematocrit (Hct): Ratio of the Votred blood cells to v of whole blood normal range: man -> 43-50% women wa 37-43%
Red cell count (RBC) erythrocyte count; not red blood cells in of blood normal range:4.2-59 million cells/mm.
White blood cell count (WBC) leukocyte count in of white blood cells in of blood. normal range: 4300010000 cells/crm
-sentinels: fixed/sentinal position in the tissue (eg: mast cells, g/x+ cells, macrophages)
Immune cells * wrong location is indiactive of a disease.
> Patrols: constantly in motion/patrolling the tissues throughout the body by circulating blood Ulymphatic vessels Ley T UB cells, neutrophil
Cluster of differentiation (CD): protocol used for the id 8investigation of cell surface targets for
molecules
providing
of cells. Act as receptor/ligands
immunophenotyping
test name normal range
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