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PCOA - Pharmaceutical Sciences Questions and Answers Graded A+

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PCOA - Pharmaceutical Sciences Questions and Answers Graded A+ What effects does change in structure and as a result biodistribution have on a drug? (Physico-Chemical Properties of Drugs) Changes the solubility, metabolism, and excretion properties of the drug within the limits of the biologica...

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  • June 7, 2023
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  • 2022/2023
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PCOA - Pharmaceutical Sciences
Questions and Answers Graded A+
What effects does change in structure and as a result biodistribution have on a drug?




(Physico-Chemical Properties of Drugs) ✔✔Changes the




solubility,

metabolism, and

excretion




properties of the drug within the limits of the biological target.




Electrolytes ✔✔Ionic/ weak acid or base




Hydrogen Bonds ✔✔Hydrogen bonds form between polar groups




Interaction between an electronegative atom (O, N, S) and a polarized hydrogen.

, Polarized H is one that is bound to an electronegative atom.




Water can accept and donate H-bonds. Competition between H-bonding between water

molecules v. H-bonding between drug and water molecules




Halogenated hydrocarbon ✔✔contain C, H, and halides (CL, F, I)




Alcohols ✔✔Contain a hydrogen bond donor and acceptor




R-OH




aldehyde ✔✔O=C-H




pKa value ✔✔Definition: a measure of the tendency to give up a proton




indicates the acid or base properties of a particular functional group




As pKa decreases, the better the acid, the easier it is to give up a proton.

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