Summary
Samenvatting Overzicht van het aangeboren en het verworven immuunsysteem - GZW1022
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Stapsgewijze samenvatting van de gehele immuunreactie
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Heleen van den Berg 2022/2023Overzicht van het aangeboren en het verworven
immuunsysteem – GZW1022
, Heleen van den Berg 2022/2023
Inhoudsopgave
Algemeen...................................................................................................................................................... 3
Eerste linie: externe, niet-specifieke afweer................................................................................................... 3
Natuurlijke barrières............................................................................................................................................3
De huid.............................................................................................................................................................3
Het spijsverteringskanaal.................................................................................................................................4
De luchtwegen.................................................................................................................................................4
De ogen............................................................................................................................................................4
De urinewegen.................................................................................................................................................4
Tweede linie: interne, niet-specifieke afweer.................................................................................................4
Humorale afweer.................................................................................................................................................5
Ontstekingsreactie...........................................................................................................................................5
Cellulaire afweer..................................................................................................................................................7
Cytokinen.........................................................................................................................................................7
Cellen van het aangeboren immuunsysteem.......................................................................................................7
Monocyten/macrofagen..................................................................................................................................7
Diapedese....................................................................................................................................................7
Fagocytose..................................................................................................................................................8
Granulocyten...................................................................................................................................................9
Natural killer cellen..........................................................................................................................................9
Mestcellen.......................................................................................................................................................9
Dendritische cellen..........................................................................................................................................9
Aangeboren immuunsysteem in het kort....................................................................................................... 9
Derde linie: specifieke afweer...................................................................................................................... 10
Antigeenrepresentatie.......................................................................................................................................10
MHC-I.............................................................................................................................................................10
MHC-II............................................................................................................................................................11
T-cellen...............................................................................................................................................................11
T-helpercellen................................................................................................................................................11
Cytotoxische T-cellen.....................................................................................................................................11
Activatie T-cellen...........................................................................................................................................12
B-cellen...............................................................................................................................................................12
Activatie.........................................................................................................................................................13
Antistoffen.....................................................................................................................................................14
Neutralisatie..............................................................................................................................................14
Opsonisatie...............................................................................................................................................14
Activatie van complementsysteem...........................................................................................................14
Verloop verworven immuunreactie....................................................................................................................14
Fase 1: Activatie T-helpercel..........................................................................................................................14
Fase 2A: Activatie B-lymfocyten....................................................................................................................15
Fase 2B: Activatie cytotoxische T-lymfocyten...............................................................................................15
Verworven immuunsysteem in het kort....................................................................................................... 15
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