Voor dit onderzoeksverslag wordt er een retrosynthese route bedacht en aan de hand daarvan een synthese route opgesteld. Dit gebeurt voor het targetmolecuul 5-broom-1,6-diethyl-3-[(1-methylpyrrolidin- 2-yl)methyl]-1H-indool.
De onderzoeksvraag die is opgesteld is: welke synthese routes kunnen word...
,Samenvatting
Voor dit onderzoeksverslag wordt er een retrosynthese route bedacht en aan de hand daarvan een
synthese route opgesteld. Dit gebeurt voor het targetmolecuul 5-broom-1,6-diethyl-3-[(1-methylpyrrolidin-
2-yl)methyl]-1H-indool.
De onderzoeksvraag die is opgesteld is: welke synthese routes kunnen worden toegepast voor de synthese
van 5-broom-6-ethyl-1H-indool vanuit 5-broom-1,6-diethyl-3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indool,
en hoe kunnen deze routes verschillen in efficiëntie, bijproducten, opbrengst (yield), duurzaamheid,
veiligheid en kosten?
Alle mogelijkheden per stap zijn bediscussieerd en er is uiteindelijk een syntheseroute opgesteld. Deze is
weergegeven in figuur 8.
De reactietijd van het totale syntheseplan is ongeveer 18 uur. Verder is de geschatte opbrengst ongeveer
80-85%.
Summary
For this research report, a retrosynthesis route is investigated and based on this a synthesis route is
established. This occurs for the target molecule 5-bromo-1,6-diethyl-3-[(1-methylpyrrolidin-2-yl) methyl]-
1H-indole.
The research question that has been formulated is: which synthetic routes can be applied for the synthesis
of 5-bromo-6-ethyl-1H-indole from 5-bromo-1,6-diethyl-3-[(1-methylpyrrolidin-2-yl)) methyl]-1H-indole,
and how might these pathways differ in efficiency, by-products, yield, sustainability, safety, and cost?
All options per step were discussed and a synthesis route was eventually drawn up. This is shown in figure
8.
The reaction time of the total synthesis plan is approximately 18 hours. Furthermore, the estimated yield is
about 80-85%.
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